every time I find a little new piece of information it seems to lead back in some way to genetic disorders that evolved due to malaria
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080723
Defining the Range of Pathogens Susceptible to Ifitm3 Restriction Using a Knockout Mouse Model
https://www.embopress.org/doi/10.15252/emmm.201809958
Toward these goals, we have contributed over the past 25 years to develop a new gene transfer system based on the human lentivirus HIV, which has become widely used in biomedical research (Naldini et al, 1996, 2016). These lentiviral vectors (LV) exploit the core machinery of HIV for efficient nuclear translocation and integration of their genetic payload into the chromatin of human cells and are packaged with the surface envelope of other viruses to allow targeting a wide range of cells....
. As more restriction factors are uncovered, new drugs become available to counteract them and enable enhanced (Wang et al, 2014; Petrillo et al, 2015; Zonari et al, 2017; Heffner et al, 2018) and better matched gene transfer among donors, as in the case of cyclosporin H, which overcomes IFITM3 restriction (Petrillo et al, 2018).
https://www.embopress.org/doi/10.15252/emmm.201809958
. Conclusion:IFITM3 rs12252 CC genotype was associated with severity rather than susceptibility of IVI in Chinese population, and this strong effect was observed in all subtypes of seasonal influenza infection
https://www.immunology.ox.ac.uk/publications/709564