German researchers identify potential drug for Covid-19

pharmaceutical-technology.com ^ | 6 March 2020 | pharmaceutical-technology

[Berlin_Freeper]

Scientists at the German Primate Center – Leibniz Institute for Primate Research have found that an existing drug may help treat Covid-19.

As well as Charité – Universitätsmedizin Berlin, the scientists worked with researchers at the University of Veterinary Medicine Hannover Foundation, the BG-Unfallklinik Murnau, the LMU Munich, the Robert Koch Institute and the German Center for Infection Research.

The research aimed to understand the entry of the novel coronavirus, SARS-CoV-2, into host cells, as well as determine approaches to block the process.

Research findings showed that SARS-CoV-2 requires cellular protein TMPRSS2 to enter hosts’ lung cells.

German Primate Center Infection Biology Unit head Stefan Pöhlmann said: “Our results show that SARS-CoV-2 requires the protease TMPRSS2, which is present in the human body, to enter cells. This protease is a potential target for therapeutic intervention.”

Furthermore, the team observed that the drug camostat mesilate, known to act against TMPRSS2, could block novel coronavirus infection, offering promise for a new treatment option (Cell).

Camostat has approval in Japan for the treatment of pancreatic inflammation.

When tested on SARS-CoV-2 isolated from a patient, camostat blocked the entry of the virus into lung cells, noted the researchers.

Study lead author Markus Hoffmann added: “We have tested SARS-CoV-2 isolated from a patient and found that camostat mesilate blocks entry of the virus into lung cells.

“Our results suggest that camostat mesilate might also protect against COVID-19. This should be investigated in clinical trials.”

[Obadiah]

I thought the Israelis were already weeks away from a cure.

All these cures cannot be good for the panic.

[Forward the Light Brigade]

Need to get to work on this Chop-chop! Same with us! Use prisoners to test it upon—Use illegal aliens—If they live—Citizenship !

[Forward the Light Brigade]

Need to get to work on this Chop-chop! Same with us! Use prisoners to test it upon—Use illegal aliens—If they live—Citizenship !

[6ppc]

Not a cure. Sounds promising as a treatment.

[null and void]

Good news!

Bring Out Your Dead

Post to me or FReep mail to be on/off the Bring Out Your Dead ping list.

The purpose of the “Bring Out Your Dead” ping list (formerly the “Ebola” ping list) is very early warning of emerging pandemics, as such it has a high false positive rate.

So far the false positive rate is 100%.

At some point we may well have a high mortality pandemic, and likely as not the “Bring Out Your Dead” threads will miss the beginning entirely.

*sigh* Such is life, and death...

If a quarantine saves just one child's life, it's worth it.

[null and void]

Green cards, maybe...

[Starcitizen]

The best drug is high-speed lead poisoning administered to the cranial region of the entire Communist Chinese politburo and leadership

[Grampa Dave]

Kaiser Seattle is in the process of recruiting volunteers for:

First coronavirus vaccine trial in the US is recruiting volunteers:

By Nicoletta Lanese - Staff Writer a day ago

Forty-five people will be enrolled in the preliminary safety trial of the new vaccine.

Researchers in Seattle have begun recruiting healthy volunteers to participate in a clinical trial for an experimental COVID-19 vaccine, according to news reports.

The vaccine, developed by the biotechnology company Moderna Therapeutics, was initially sent to the National Institute of Allergy and Infectious Diseases (NIAID) in Maryland on Feb. 24, according to The Wall Street Journal. The agency anticipates launching a clinical trial by the end of April and will sponsor the Kaiser Permanente Washington Health Research Institute to conduct the testing, NIAID Director Anthony Fauci told The Wall Street Journal.

Forty-five healthy volunteers between the ages of 18 and 55 will be enrolled in the initial trial, which aims to determine whether the vaccine triggers an immune response, and whether the given dose causes adverse side effects, according to a description on ClinicalTrials.gov.

https://www.livescience.com/us-coronavirus-vaccine-trial-recruiting.html

[Abathar]

“Our results suggest that camostat mesilate might also protect against COVID-19. This should be investigated in clinical trials.”

“Gretchen!! Order us 10 cases if this drug STAT for testing!”

“We can’t sir, the production was off-shored 4 years ago to a facility in Wuhan.”