ping
“... some novel coronavirus cases, patients who developed only moderate symptoms at the onset of the disease later fell seriously ill and died of multiple organ failure.”
that’s scary
From the article...
Zhou said the novel coronavirus can stimulate the body’s immune system, which can further damage the cells.
“A normal immune system protects, but an over-active immune system can not only damage the lungs but also other organs, including the kidneys, liver and heart,” he said.
.????
“He termed the condition a “storm of inflammations””
SARS caused cytokine storm as well.
Basically, what made the Spanish flu so deadly. Somehow, young people seem to have been mostly spared. So far.
The coronavirus can last a while before the downturn from what I’ve read. A case in point is the whistleblower Dr. Li Wenliang. He started having mild symptoms on Jan 10, tested negative several times, finally tested positive on Jan 20, and died on Feb 6.
Hopefully, allowed to quote the article...
“But for other patients, new treatments can calm the storm and bring remarkable recoveries. Cron and Behrens “both got interested in this through a patient we saw in Pennsylvania,” Cron said. “Probably the sickest patient I ever saw come out of the ICU unscathed.” The doctors treated her with anakinra, a cytokine-targeting therapy that was approved to treat the autoimmune disease rheumatoid arthritis. “She turned around and it was magical,” Cron recalled. “We’re both research scientists, so he developed a mouse model [of cytokine storm syndrome] and I’ve been studying the genetic and human aspects. We’ve identified new genes not previously described as a part of this genetic workup.”
In 2016, Cron and Winn Chatham, M.D., professor in the Division of Clinical Immunology and Rheumatology, began a clinical trial at UAB and Children’s Hospital to study the safety of anakinra in patients with signs of severe, potentially life-threatening inflammation. Cron is director of the Division of Pediatric Rheumatology at Children’s of Alabama. Anakinra is “remarkably safe,” and following this initial study, the researchers hope to begin a larger trial in the future”.
From here;
https://www.newswise.com/articles/here-s-a-playbook-for-stopping-deadly-cytokine-storm-syndrome
cytokene storms not very treatable; mixed results with NAC and steroiods; however the following works, but probably would be available only to the super-rich elite at this point:
..”A storm of inflammations”..
Horrible.
This is why I brought a bottle of Benadryl tablets with me.
I had a flu/allergy bout last week in Northern Laos, just south of the China border. When my lungs started filling up I drank lots of hot coffee and took Benadryl. It saved me from pneumonia.
For a day I felt like my head was going to explode, but my chest cleared up real fast.
Maybe 'the storm' doesn't happen until the second or third time a person is infected... this IS a weapon after all...
whoops, sorry, that was yours. [blush]
.
I (think) the source was
over on a thread at Instapundit, writes:
I'm not a doctor, but based on this remark in the Live Science article about the relatively few children who're victims of the Corona virus I will hazard a guess that extends what it says in this remark.
The innate immune system is the first line of defense against pathogens. Cells in that system respond immediately to foreign invaders. (The adaptive immune system, by contrast, learns to recognize specific pathogens, but takes longer to join the battle.) If the innate immune response is stronger in children exposed to 2019 nCoV, they may fight off infection more readily than adults, suffering only mild symptoms.
It seems sensible to assume that the innate immune system protecting a child's lungs must be more effective than that in adults. Their breathing passages are shorter and their adaptive immune system has yet to learn what pathogens to fight. That stronger innate immune response (attacking anything foreign) may give them added protection against a virus like the Corona.
One peculiarity of the Corona virus is that its infection must plant itself well inside our lungs. Throat swabs often fail to detect it. That contrasts with many other viral infections that first settle in our throats and then move to our lungs. A throat infection is uncomfortable but not deadly and gives our adaptive immune system to prepare to fight it before it reaches our lungs, where it can be lethal. Because the Corona virus bypasses our throat and infects our lungs directly, the response of our adaptive immune system is delayed.
Of course, there's also another factor suggested by the article, that the immune system of adults overreacts to a Corona virus infection, making matters worse.
Adults are also more susceptible to a detrimental immune response that causes a condition called acute respiratory distress syndrome (ARDS), said Dr. James Cherry, a professor of pediatrics and infectious diseases at UCLA's Geffen School of Medicine. A complicated imbalance of immune cell activity sends inflammation into the lungs into overdrive, ultimately causing fluid to fill the alveoli, or air sacs, according to research published in the journal Annals of Translational Medicine
ARDS is the primary way that the Corona kills.