John C Reilly has to be just about the ugliest person well except for Ron Perlman.
He tries hard and he has been in a lot of varied roles, from the clueless husband in Chicago to an Irish gang banger in Gangs of New York to a video game character in Wreck It Ralph. I wish him success just because he's so ugly. Not all of the Hollywood stars have to be beautiful people.
What about Clint Howard?