Depends on the type of runner. A pro runner runs to contact, keeps his feet moving and spins off the contact. This wears down defenders and a 3 yd rushing avg can jump when he breaks 1 late. All they need is a small seam. Makes the O-line look & play better since they learn never to give up on a play.
Most collegiate runners are looking for a hole and go down at the slightest contact. These guys don’t do well in the pros.
Barry Sanders is a perfect example, and Barkley has looked a lot like him through his first few games. Sanders could run for 150 yards on 20 carries in a game, but when you looked closely at his games you'll see that he was very ineffective despite all those yards. In his typical 150-yard game he'd have two long runs of 60 yards each, then just 30 yards on his other 18 carries. That's an awful recipe for an offense in the NFL, because the team can't run a ball-possession offense and usually faces situations of 2nd-and-9, 3rd-and-7+, etc.