Posted on 01/23/2018 8:35:24 PM PST by BenLurkin
Exactly how curcumin exerts its effects is not certain, but it may be due to its ability to reduce brain inflammation, which has been linked to both Alzheimers disease and major depression, said Dr. Gary Small, director of geriatric psychiatry at UCLAs Longevity Center and of the geriatric psychiatry division at the Semel Institute for Neuroscience and Human Behavior at UCLA, and the studys first author.
The double-blind, placebo-controlled study involved 40 adults between the ages of 50 and 90 years who had mild memory complaints. Participants were randomly assigned to receive either a placebo or 90 milligrams of curcumin twice daily for 18 months. All 40 subjects received standardized cognitive assessments at the start of the study and at six-month intervals, and monitoring of curcumin levels in their blood at the start of the study and after 18 months. Thirty of the volunteers underwent positron emission tomography, or PET scans, to determine the levels of amyloid and tau in their brains at the start of the study and after 18 months.
The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not, Small said. In memory tests, the people taking curcumin improved by 28 percent over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos.
The amygdala and hypothalamus are regions of the brain that control several memory and emotional functions. Four people taking curcumin, and two taking placebos, experienced mild side effects such as abdominal pain and nausea.
(Excerpt) Read more at universityofcalifornia.edu ...
I am boarded in toxicology, which is why I get funded by drug companies that must be certain of MTDs.
I have worked with nanoparticle platforms for cancer chemotherapeutics since 2003 and just received notice of a second patent. Particle size is one small piece of the BBB puzzle. YOU are not your wife, ok. You brag about some engineering degree—what type of engineer?
I didn’t look anything up. I’ve worked in the area for well over a decade and have several refereed publications. If you have a wallet I would be happy to make you a wager? As the old saying goes put the money where the mouth is.
What kind of an engineer are you?
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