Sure, no problem.
Sounds to me like you are sensitive to my use of the term "junk DNA", but from a scientific perspective, that's fine.
And the fact that "junk" fell from over 90% in, say, 1975 to just 65% now doesn't much impress you.
You wish us to understand there's much more function than we yet acknowledge, fine.
So remind me, is there a larger point?
“”And the fact that “junk” fell from over 90% in, say, 1975 to just 65% now doesn’t much impress you.”
Empty rhetoric.
Provide a reference.
You both seem to have big issues with Creationists and with popular arguments over “junk DNA”m
You also both seem to know little more of DNA than that it codes for proteins, and the old idea that, therefore, all other sequences are non-functional filler.
One cites Phil Sharp’s 1977 discovery of introns, which would put the non-coding portion on mammals at 98% or so, another says it was 90% in 1975 (before introns were ever discovered).
There’s no reason not to laugh or make fun of both or either of you.
But I don’t and know you are FRiends.
So I will try to walk you through the most recent findings in the amazing world of nucleic acids and the key importance of non-coding DNA.
This is great stuff and reflects how intricate, multifunctional and complex DNA is.
We can start with a 2017 articles from Phil Sharp.
https://www.ncbi.nlm.nih.gov/pubmed/28283057
Cell. 2017 Mar 9;168(6):1000-1014.e15. doi: 10.1016/j.cell.2017.02.015.
Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis.
Suzuki HI1, Young RA2, Sharp PA3.
Super-enhancers are an emerging subclass of regulatory regions controlling cell identity and disease genes. However, their biological function and impact on miRNA networks are unclear. Here, we report that super-enhancers drive the biogenesis of master miRNAs crucial for cell identity by enhancing both transcription and Drosha/DGCR8-mediated primary miRNA (pri-miRNA) processing. Super-enhancers, together with broad H3K4me3 domains, shape a tissue-specific and evolutionarily conserved atlas of miRNA expression and function. CRISPR/Cas9 genomics revealed that super-enhancer constituents act cooperatively and facilitate Drosha/DGCR8 recruitment and pri-miRNA processing to boost cell-specific miRNA production. The BET-bromodomain inhibitor JQ1 preferentially inhibits super-enhancer-directed cotranscriptional pri-miRNA processing. Furthermore, super-enhancers are characterized by pervasive interaction with DGCR8/Drosha and DGCR8/Drosha-regulated mRNA stability control, suggesting unique RNA regulation at super-enhancers. Finally, super-enhancers mark multiple miRNAs associated with cancer hallmarks. This study presents principles underlying miRNA biology in health and disease and an unrecognized higher-order property of super-enhancers in RNA processing beyond transcription.