You both seem to have big issues with Creationists and with popular arguments over “junk DNA”m
You also both seem to know little more of DNA than that it codes for proteins, and the old idea that, therefore, all other sequences are non-functional filler.
One cites Phil Sharp’s 1977 discovery of introns, which would put the non-coding portion on mammals at 98% or so, another says it was 90% in 1975 (before introns were ever discovered).
There’s no reason not to laugh or make fun of both or either of you.
But I don’t and know you are FRiends.
So I will try to walk you through the most recent findings in the amazing world of nucleic acids and the key importance of non-coding DNA.
This is great stuff and reflects how intricate, multifunctional and complex DNA is.
We can start with a 2017 articles from Phil Sharp.
https://www.ncbi.nlm.nih.gov/pubmed/28283057
Cell. 2017 Mar 9;168(6):1000-1014.e15. doi: 10.1016/j.cell.2017.02.015.
Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis.
Suzuki HI1, Young RA2, Sharp PA3.
Super-enhancers are an emerging subclass of regulatory regions controlling cell identity and disease genes. However, their biological function and impact on miRNA networks are unclear. Here, we report that super-enhancers drive the biogenesis of master miRNAs crucial for cell identity by enhancing both transcription and Drosha/DGCR8-mediated primary miRNA (pri-miRNA) processing. Super-enhancers, together with broad H3K4me3 domains, shape a tissue-specific and evolutionarily conserved atlas of miRNA expression and function. CRISPR/Cas9 genomics revealed that super-enhancer constituents act cooperatively and facilitate Drosha/DGCR8 recruitment and pri-miRNA processing to boost cell-specific miRNA production. The BET-bromodomain inhibitor JQ1 preferentially inhibits super-enhancer-directed cotranscriptional pri-miRNA processing. Furthermore, super-enhancers are characterized by pervasive interaction with DGCR8/Drosha and DGCR8/Drosha-regulated mRNA stability control, suggesting unique RNA regulation at super-enhancers. Finally, super-enhancers mark multiple miRNAs associated with cancer hallmarks. This study presents principles underlying miRNA biology in health and disease and an unrecognized higher-order property of super-enhancers in RNA processing beyond transcription.
{sigh} You're hopeless.
[[So I will try to walk you through the most recent findings in the amazing world of nucleic acids and the key importance of non-coding DNA.]]
This is exactly why i asked exdemmom what % of the genes were to be discounted and what % similarity this would wind up being between chimps and humans- i got no answer- She caled the author of the original article a liar- deceiver or soem such ridiculing comment- psuedoscience was another big bash- but when asked she couldn’t brign herself to answer the question
[[This is great stuff and reflects how intricate, multifunctional and complex DNA is.]]
That’s what i was wondering- how much of the ‘irrelevant’ coding was actually relevant, or even species specific- I noted she was careful to say “”Little” to “None” function- one of the sites i listed stated that when they come up with the 98% figure they do so throwing out important coding- granted, all may not be essential, but I’m sure some was more essential than others but still thrown out- which again is why i asked for a guesstimate on how much actual ‘irrelevant’ coding we’re actually talking about?