“David Sinclair has been reverse-engineering the aging process for two decades.”
David Sinclair, now in his early twenties, has been reverse-engineering the aging process for two decades.
I personally think aging and death are kind of a gift to Society. If not for that, people like the Clintons and Bushes would never let go.
Very interesting, to an old fart currently taking Metformin.
This is available on Amazon.
For starters it’s MetforMin not MetforNin. Geeze. It’s repeated like that 6,7-8 or more times. If I headed the FDA I’d insist they start their proposed ‘study’ with demolishing their spell checker.
Aging is not a disease. It is part of being a living organism.
Eat asparagus. Use soy lecithin.
Science advances one funeral at a time...
A simple answer to this so called problem is to go back to allowing doctors to rx any FDA approved drug for any indication where the drug works, regardless of the FDA approval. The doctor can check to see if that drug has been approved in other countries and use their studies for his/her info base.
This restriction re not allowing doctors to rx any FDA approved drug for unapproved indications started during the LBJ years.
Those rules made FDA into a left wing controlled gate keeper of uses of any FDA approved drug. That enabled the University Medical Schools to be able to set up expensive clinical trials to approve the drugs for new indications. Many if not most medical schools are left wing controlled organizations.
This blocking of the use of non FDA approved indications has added billions of $’s to the cost of drugs that had been approved and doctors are aware of that drug’s side effect profile. A drug that might work for many indications is often restricted by FDA to only the original indication in the original NDA. (New Drug Application)
The answer is simple. Go back to days where legitimate real world doctors used a FDA approved drug for unapproved indications and presented their results to other doctors at meeting and via published papers.
With Google search and other search systems, a doctor with a patient with X disease could quickly search the data base of FDA approved drugs that have a positive treatment profile with non FDA approved indications.
Today, that doctor might be hammered for trying to help his/her patients by rxing a FDA approved drug for “an unapproved” indication. Many RX plans will not help pay for “unapproved” indications.
Last, but not least, the real world of patients getting an rx from their doctor is the best test of any drug re efficacy and safety. I would rather trust the results of hundreds or thousands of good doctors using X drug for any indication versus many Med School center’s studies.
It has at least one that's significant, if not recognized. It interferes with absorption of B12 and, IIRC, is reported to cause B12 deficiency in up to a third of folks on it. I was one. Happily that's correctible with B12 supplementation orally. If you've been on metformin, aren't taking B12 and haven't been checked get a simple B12 level test. B12 deficiency can cause anemia, or neurologic problems, if not recognized. Don't wait for the latter to learn you have it.
Exercise also helps. Been exercising religiously since age of 15 (50 years) and when home-rehab folks came in after my hip replacement (wore it out by running far enough to go around the world and then some) they told me that I wasn’t the typical 65 year old that needed their help doing the right exercises - they said I was “an apparent 50” in good enough shape to be as vital as the average 40 year old.
My grandmother lived to be 95, my mother is currently 92 and my MIL is 90.
I have no desire to be alive, with the lives the two living ones have.
My wife feels the same, btw.
Calling something a disease does not make it a disease.
Disease - definition - a disorder of structure or function in a human, animal, or plant.
Disorder - definition - to disturb (or a disturbance of) the [natural] order of something.
Since aging occurs in all life - human, animal, or plant, it must be assumed it is part of the natural order of life, and not a disease contrary to that natural order.
It may have a cause or causes, but to call any of them a disease is neither truth of science.
Can the natural order - aging and death - be delayed by things we can do, or things we can take that actually “disturb the natural order” such as to delay and/or reduce the aging process. Doing so still does not make aging a disease.
If I understand the mechanism correctly, it acts somewhat like a proper-diet-and-exercise in pill form; so we shouldn’t expect any life extension greater than what you could hope to get from the real thing.