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Is it dangerous to block the D1 receptor?

If the drug is harmless, I would like to see it added to alcohol products.

See also reader comments.

1 posted on 09/05/2015 3:11:59 PM PDT by UnwashedPeasant
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To: UnwashedPeasant

But ... But I enjoy mah Beer!


2 posted on 09/05/2015 3:17:01 PM PDT by Red_Devil 232 ((VietVet - USMC All Ready On The Right? All Ready On The Left? All Ready On The Firing Line!))
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To: UnwashedPeasant

The reason drugs have side effects in some people and not in others is the body uses the same mechanisms over and over to do different things so non-targeted nerves are equally affected. The other reason is people’s nerves are slightly different from each other in nerve density and layout. Sort of like some trees have lots of branches and loads of leaves and others of the same species have fewer branches and fewer leaves. You probably know somebody who salts the heck out of his food and can drink hot sauce from the bottle while others never salt their food and can’t bear hot sauce. Those preferences are likely caused by different nerve density or layout.


3 posted on 09/05/2015 3:19:24 PM PDT by Gen.Blather
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To: UnwashedPeasant

The article above links to this other article that is longer and more informative:

http://www.sciencedaily.com/releases/2015/09/150902155642.htm


4 posted on 09/05/2015 3:22:46 PM PDT by UnwashedPeasant (A slave is one who waits for someone to come and free him.)
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To: UnwashedPeasant

The cure already exists. It is called abstinence. Will also work fro drug addiction, sex addiction, gambling addiction, tobacco addiction and all other so-called “addictions” that can simply be cured by NOT DOING THEM.

Stupid freaking concept that you need a “cure” for addiction.

“Dr. it hurts when I do this!”

“Don’t do that.”

Yeah. It is that simple.


5 posted on 09/05/2015 3:23:37 PM PDT by jessduntno (The mind of a liberal...deceit, desire for control, greed, contradiction and fueled by hate.)
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To: UnwashedPeasant

I’m buzzed on half a glass, so I don’t have to worry about drinking a bottle.


6 posted on 09/05/2015 3:32:33 PM PDT by DLfromthedesert (www.ouramericanrevival.com)
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To: UnwashedPeasant

This will likely go nowhere. Too many people making obscene amounts of money from alcoholism.


7 posted on 09/05/2015 3:33:59 PM PDT by upchuck (Drinking buddies and BFFs: Satan, nobama and the AntiChrist. Different subject: Go CRUZ!)
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To: UnwashedPeasant

Will it help the Injuns?


9 posted on 09/05/2015 3:34:55 PM PDT by Cowboy Bob (With Trump & Cruz, America can't lose!)
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To: UnwashedPeasant

I’m an alcoholic who hasn’t had a drink in 15 years. Gosh, I never would have thought it possible when I was drinking, but I like being sober.


10 posted on 09/05/2015 3:38:12 PM PDT by Fido969
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To: UnwashedPeasant

With 21 years and 7 months sober today, I am skeptical of solutions other than abstinence.

If there was a drug that I could take to reduce the craving for the next drink, I am better off not having the first drink.


13 posted on 09/05/2015 3:51:26 PM PDT by truth_seeker (come with the outlws.)
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To: UnwashedPeasant; All

Too funny....They are finally proving what the Doctor’s Opinion has stated for 80n years

It is and obession of the mind and an allergy of the body. Once the craving starts alcoholics do no react like normal drinkers.

Every drunk I know can testify to that fact.

There is another way out


14 posted on 09/05/2015 3:55:10 PM PDT by Nifster (I see puppy dogs in the clouds)
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To: UnwashedPeasant
Abilify

The buzz is about its mechanism of action, which is unique among currently approved antipsychotics. Rather than being a dopamine blocker, it is a “dopamine system stabilizer”.

http://pro.psychcentral.com/abilify-the-perfect-antipsychotic/001493.html

15 posted on 09/05/2015 3:56:25 PM PDT by HangnJudge (Cthulhu for President, why vote for a lesser Evil)
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To: UnwashedPeasant

Aw crap. There goes AA.


21 posted on 09/05/2015 4:07:43 PM PDT by Lazamataz (Ok. We won't call them 'Anchor Babies'. From now on, we shall call them 'Fetal Grappling Hooks'.)
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To: UnwashedPeasant

BTTT


24 posted on 09/05/2015 4:17:59 PM PDT by Fiddlstix (Warning! This Is A Subliminal Tagline! Read it at your own risk!(Presented by TagLines R US))
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To: UnwashedPeasant

I nominate Speaker Boehner as the First Human Trial Subject.


25 posted on 09/05/2015 4:18:55 PM PDT by eyeamok
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To: UnwashedPeasant

But how will you make a “2” appear as a “10” around closing time?


35 posted on 09/05/2015 5:08:31 PM PDT by Larry Lucido
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To: UnwashedPeasant

Good news for John Boehner.


54 posted on 09/05/2015 6:43:36 PM PDT by Ranger Warrior
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To: UnwashedPeasant

Back to the topic.

There are a few drugs that D1 Dopamine Receptor Antagonists. Some of the drugs are listed here:

https://en.wikipedia.org/wiki/Dopamine_receptor_D1#Antagonists


56 posted on 09/05/2015 7:00:59 PM PDT by UnwashedPeasant (A slave is one who waits for someone to come and free him.)
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To: UnwashedPeasant

More good info here, including a list of names for D1-receptor-blocking drugs and their side effects:

http://alcoholrehab.com/drug-addiction/dopamine-antagonists/


62 posted on 09/05/2015 8:00:37 PM PDT by UnwashedPeasant (A slave is one who waits for someone to come and free him.)
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