The Abbasid Caliphate disposed of it about 750 AD ~ tore down the walls, reduced it to a village or town, and removed economic activity from the area ~ and that was that. There are other similar events in its history ~ much of which precedes that of the Hebrews ~ couple of references to ‘something’ in the area back as far as 9000 BC
It was destroyed but came back. The Bible says it will be destroyed and no one will live there again. I had figured that meant an atomic blast if no one could live there again. I just read one of our ships off the coast of Syria is a nuclear weapon carrying ship. I can't imagine a nuclear bomb would be used.
In the past two months, Israel has asked Jordan twice to bomb the chemical weapons as Mossad knows where they are. Jordan has said “not yet”. That's because some of those chemical stores are close to the Jordanian border.
****reduced it to a village or town****
Damascus will be completely uninhabited, that is the prophecy and has not happened yet.