It was destroyed but came back. The Bible says it will be destroyed and no one will live there again. I had figured that meant an atomic blast if no one could live there again. I just read one of our ships off the coast of Syria is a nuclear weapon carrying ship. I can't imagine a nuclear bomb would be used.
In the past two months, Israel has asked Jordan twice to bomb the chemical weapons as Mossad knows where they are. Jordan has said “not yet”. That's because some of those chemical stores are close to the Jordanian border.
That's happened more than once to Damascus.
Now, regarding Western Europe, that happened sometime between 535AD and 541AD ~ whole place turned into a cow pasture ~ and in many places that condition persisted for a thousand years.
Damascus only got destroyed once during that period of Biblical sized devastation ~ Paris, London, and all the cities of the North German Plain were utterly destroyed ~ so, tell me, how did Isaiah miss that?