Posted on 07/02/2009 5:14:48 AM PDT by decimon
UC Irvine anesthesiology study finds melatonin reduces emergence delirium rates
A scary unknown for many children, the prospect of surgery can cause intense preoperative anxiety. While some amount of stress is normal, what many parents do not know is that extreme anxiety before surgery can contribute to the occurrence of emergence delirium, a distressing incidence of acute behavioral changes experienced when "waking up" from anesthesia.
Now in the July issue of Anesthesiology, physicians focused on reducing anxiety in children and their families report that oral treatment with melatonin before surgery can significantly reduce the occurrence of emergence delirium in children.
Affecting up to 20 percent of children who undergo surgery, emergence delirium in the post-anesthesia care unit (PACU) consists of acute behavior changes including crying, thrashing and need for restraint. According to researchers, this can also lead to the development of behavioral changes outside the recovery suite with the onset of nightmares, bed wetting and separation anxiety.
"Studies conducted in adults have revealed that oral administration of melatonin before surgery beneficially reduced anxiety levels, but relevant similar treatment data for children undergoing anesthesia and surgery are limited," said study lead author Zeev N. Kain, M.D., MBA, Chair of UC Irvine Anesthesiology and Associate Dean for Clinical Research at the UC Irvine School of Medicine.
Seeking confirmation of additional options for anxiety management, researchers first set out to determine if melatonin could decrease anxiety levels when compared to midazolam, a sedative widely used to ease preoperative anxiety. Melatonin is a hormone secreted by the pineal gland, regulates sleep, moods and reproductive cycles. Secretions of melatonin increase during exposure to light.
In a study group that consisted of 148 subjects between the ages of 2 and 8 undergoing outpatient surgery under general anesthesia, children were randomly assigned to receive midazolam or melatonin orally before surgery. Children were followed throughout their surgical experience as researchers measured anxiety and secondary study outcomes of anesthesia administration compliance and emergence behavior. Behaviors were measured using the Yale Preoperative Anxiety Scale (mYPass), the Induction Compliance Checklist and the Keegan scale.
"Results indicated that preoperative melatonin administration did not effectively reduce anxiety levels," said Dr. Kain. "However, it was found that melatonin significantly reduced the incidence of emergence delirium in these children. As 3 million children undergo surgery in the U.S. each year, these findings reveal noteworthy health care and treatment implications."
Melatonin showed a direct dose dependent effect on emergence delirium. Children in the melatonin premedication group received any of three doses of melatonin: 0.05 mg/kg, .2 mg/kg and 0.4 mg/kg, while the incidence of delirium at each dose was 25 percent, 8.3 percent and 5.4 percent.
Midazolam remains the recommended premedication for anxiety reduction in children scheduled for surgery.
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For more information visit the journal Anesthesiology at www.anesthesiology.org.
While some amount of stress is normal, what many parents do not know is that extreme anxiety before surgery can contribute to the occurrence of emergence delirium, a distressing incidence of acute behavioral changes experienced when “waking up” from anesthesia.
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I was a recovery room R.N. in a “tonsil unit” for a summer.
This post surgery delirium in children is terrifying for the children, and hard to manage for the nurses.
My tonsils were removed when I was five. What helped me was being told that ice cream was part of the recuperation.
Interesting stuff about melatonin.
L
Look for the FDA to call for it’s regulation.
What do they use for anesthetic? The sodium pentothal type stuff is wicked.
And for me. Popular with geezers, they say.
I hope not. It's inexpensive and, AFAIK, harmless.
Heck...I'm well into my 40's (wink,wink) and I just had my first *real* operation (I had some teeth pulled in an OR when I was in my 20's) last year...a hip replacement.I was told that everything would be fine.But while in the preop waiting area I got so scared that I wrote a note reminding everyone where my will was located and asked that it be brought out to my family.
If that can happen to an adult imagine what fear can come to a kid.I wonder if it might even be wise not to tell the kid what's gonna happen....just tell him/her "it's gonna be OK,sweetheart...we're gonna fix you up as good as new".
I take a small dosage to help me sleep, normally around a full moon. My doc actually recommended it...said it’s good for breast health too. I really think that the FDA and drug companies don’t like “natural” products that work, and will do everything they can to control the supplement industry.
Look into inositol. It’s a form of b-vitamin that worked wonders for me. I had severe panic attacks after I had my gallbladder removed. My doctor recommended it and it was like magic. They’ve done studies on kids with OCD, panic attacks, ADD, and it seems to help with that as well.
Is that one of the ones that the FDA is now regulating as a drug?
It is a different form of it that is being regulated. I remember being nervous when I saw that article pop up on FR, but reading into the thread, I realized it was a different compound than the one I take.
Affirmative action wasn't just for law schools...
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