Or, it could be something like the seed oils that we consume. Soy has a lot of phyto-estrogen and was not really consumed as food in the U.S. until the early 1960s. Before that its approved use was glue for cardboard fabrication. (Quite step up. Then there is “Canola oil” modified rape seed oil previously used as marine lubricant and paint ingredient.)
There’s that, too.