I would have concerns that all these new weight-loss drugs are going to have some nasty long-term side effects that won’t surface right away. Remember, kids, that cigarettes were once marketed not necessarily unreasonably as a weight-loss aid— overtly (”Reach for a Lucky instead of a sweet”) and later more subtly (Virginia SLIMS).
How about just eating less? Anyone can and will lose weight with calorie restriction.

From the 1940 through the end of the 1960s, with the best will in the world, doctors were prescribing diethylstilbestrol to prevent miscarriage, premature labor and just about every other pregnancy problem under the sun.
Turned out it did not work.
But it did give the children exposed in utero some lovely parting gifts. Like low fertility and raised cancer rates.
And it looks like these gifts are being passed on to the third generation.
I am not saying don't take it. I am saying be careful.
And if you have the possibility of becoming or of making someone pregnant be really really careful.
Some actions have really long shadows.
I think you’re right. Anything that is manipulating multiple endocrine organs is going to eventually be found to cause endocrine problems…..maybe even endocrine cancers. Just my opinion.
So far, they will only admit that they cause kidney stones.
But they also warn that GLP-1 receptor agonists (GLP-1 RAs) should not be taken by individuals with a personal or family history of multiple endocrine neoplasia type 2 (MEN2) or medullary thyroid carcinoma (MTC) due to an increased risk of thyroid cancer associated with these conditions. There’s a reason for that.
they do have horrible side effects, and are well known.