There was a 14% reduction in skin cancer risk, but if taken after the first skin cancer (and not subsequent ones), 54%.
It was a higher than normal dose taken of 500 mg twice a day for at least one month.
Bookmark.
“500 mg twice a day for at least one month.”
That’s the problem with these findings. Is that for the rest of your life? Once a year treatment. Once every six months? Bimonthly?
Google AI:
Nicotinamide (also known as niacinamide) is a form of vitamin B3 used to treat and prevent niacin deficiency, address various skin conditions, and reduce the risk of certain skin cancers. It is also being studied for potential therapeutic uses related to aging and other health issues.
For skin conditions
Nicotinamide is widely used in both oral and topical forms to improve skin health.
Acne: Its anti-inflammatory properties can help to reduce acne lesions and regulate oil production.
Rosacea and atopic dermatitis: Nicotinamide can help reduce inflammation and soothe irritation caused by these conditions.
Hyperpigmentation: It can help treat melasma and other skin discoloration by brightening the complexion.
Aging skin: Topical nicotinamide may improve skin elasticity and reduce the appearance of fine lines and wrinkles.
Skin barrier function: It helps rebuild the skin’s lipid barrier, which improves hydration and protects against irritants.
For skin cancer prevention
Studies have shown that oral nicotinamide can help prevent new non-melanoma skin cancers (basal cell and squamous cell carcinomas) and actinic keratoses in high-risk patients. It does this by boosting cellular energy and enhancing DNA repair, which protects against UV damage.
For niacin deficiency
Nicotinamide is a primary treatment for pellagra, a disease caused by severe niacin deficiency. In contrast to niacin (nicotinic acid), nicotinamide does not cause the unpleasant flushing that can be associated with higher doses.
For other medical research
Scientists are also investigating nicotinamide’s potential role in treating other conditions:
Type 1 diabetes: Nicotinamide may help delay the onset of type 1 diabetes, but more research is needed.
Cancer therapy: It is being studied as an agent that can make cancer cells more susceptible to radiation therapy and chemotherapy.
Neurological diseases: As a precursor to the coenzyme NAD+, it is being explored for its potential to help prevent neurodegenerative diseases.
Important considerations
While nicotinamide is generally well-tolerated, it is a water-soluble vitamin and is not a substitute for a balanced diet. Supplements should only be taken under medical supervision, especially at high doses.
some info from the above article:
Mechanisms of Action Relevant to Cancer Prevention Nicotinamide's potential to prevent cancer is linked to several biological mechanisms, supported by empirical data:
Enhancement of DNA Repair: UV radiation and other carcinogens cause DNA damage, which can lead to mutations and cancer if unrepaired. Nicotinamide boosts NAD+ levels, supporting PARP activity and base excision repair pathways (Surjana et al., 2013, Photodermatology, Photoimmunology & Photomedicine).
Reduction of UV-Induced Immunosuppression: UV exposure suppresses local immune responses in the skin, allowing precancerous cells to proliferate. Nicotinamide has been shown to counteract this effect in human studies (Yiasemides et al., 2009, British Journal of Dermatology).
Antioxidant Properties: Nicotinamide reduces oxidative stress, a contributor to DNA damage and carcinogenesis, as demonstrated in in vitro studies (Benavente et al., 2009, Current Molecular Medicine).
Energy Metabolism Regulation: By supporting NAD+ synthesis, Nicotinamide influences cellular energy metabolism, which is often dysregulated in cancer cells (Warburg effect). This mechanism is less studied in clinical settings but shows promise in preclinical models.
4. Safety and Dosage Considerations Recommended Dosage for Skin Cancer Prevention: Based on the ONTRAC trial and subsequent reviews, a dose of 500 mg twice daily is commonly cited as effective and safe for NMSC prevention in high-risk individuals. Lower doses (e.g., 500 mg once daily) have shown some efficacy in smaller studies but with less consistent results.
Safety Profile: Nicotinamide is generally well-tolerated at doses up to 3,000 mg per day. Unlike niacin, it does not cause flushing. However, high doses may lead to gastrointestinal upset, dizziness, or rare cases of liver enzyme elevation (Knip et al., 2000, Diabetologia).
Contraindications: There is limited data on long-term use in cancer prevention, and caution is advised in patients with liver disease or diabetes, as Nicotinamide may affect glucose metabolism.
Thanx for posting. I’m taking it. Now I understand why. lol
Specifically, it's Beta-Dihydronicotinamide Mononucleotide...
https://tinyurl.com/r56tearb
I also take Liposomal Nicotinamide Riboside (NR).
https://tinyurl.com/y2m2tzcm
I feel a "warmth" when I take them - not actually a flush, though...