Grapefruit Warning: It Can Interact with Common Medications

Healthline ^ | March 15, 2023 | Medically reviewed by Dena Westphalen, PharmD — Written by Matthew Thorpe, MD, PhD

[kaktuskid]

CBD medications have the same affect as grapefruit on blood thinners- which means you should avoid them.

[butlerweave]

Don’t forget cranberry juice

[one guy in new jersey]

Cagney, what an animal...

[dfwgator]

I always chew a little Juicy Fruit afterwards.

---

It’s good for your soul.

[packrat35]

Ah, Mae Clarke! I got this photo with her autograph in the mail. She wrote that James Cagney was a perfect gentleman when filming this scene.

[montag813]

Grapefruit seed extract does not have this side effect, and provides a much more concentrated antioxidant benefit than the fruit alone.

I take this every time I feel something "off" in my throat (that decades of life have proven to be an onset of a cold or flu), and in the morning it is always gone:

Pure Encapsulations Grapefruit Seed Extract, 60 Capsules

I used to megadose B complex, but don't need to anymore because of this amazing stuff. My wife doesn't like capsules, and sprays this stuff into the back of her throat. Just as effective:

NutriBiotic – GSE, 2 Oz Liquid | The Original Grapefruit Seed Extract Premium Concentrate with Bioflavonoids | Potent Immune & Overall Health Support

[egfowler3]

Thanks for the post! Although I already knew about the statin issues, grapefruit’s impact on so many other meds is surprising. Since leaving the US Army, I’ve been unable to eat my favorite fruit per my pharmacist due to interactions. Yuck!

Again, thanks.

[EinNYC]

I think you forgot Metformin. When I first began taking it, my doctor warned me not to eat grapefruit or drink grapefruit juice. Not even to eat grapefruit-flavored fruit drops.

[Red Badger]

BRAVE AI:

Metformin and Grapefruit Interaction
There is no strong evidence to suggest that metformin reacts with grapefruit. According to multiple sources, including medical articles and expert opinions, there is no scientific evidence indicating that grapefruit affects the safety or effectiveness of metformin.
The body does not metabolize metformin, and it is excreted unchanged in the urine, which means that grapefruit’s ability to block certain enzymes does not impact metformin.

However, some studies have suggested a potential interaction in animal models. For instance, a 2009 study on non-diabetic rats found that combining grapefruit with metformin increased lactic acid production, raising concerns about lactic acidosis.
Despite this, no human studies have confirmed such an interaction, and the FDA does not list grapefruit as a food to avoid while taking metformin.

Some sources also note that while grapefruit juice may have beneficial effects on blood sugar levels, it is still advisable to consult a healthcare provider before making any dietary changes while on metformin.
Additionally, there is a suggestion that grapefruit may interact with other medications metabolized by the CYP3A4 enzyme, but metformin is not affected by this interaction.

AI-generated answer. Please verify critical facts.

https://www.medicalnewstoday.com/articles/323603

[copaliscrossing]

Grapefruit is a delicious citrus fruit

I stopped reading right there... ha ha ha. Just kidding. To me, grapefruit is pretty nasty tasting. Gotta sprinkle with something... salt, sugar, SOMETHING!

[EinNYC]

Well, I am following my doctor’s explicit instructions.

[Red Badger]

Yes, that is best...............

[kawhill]

Midazolam (Versed). I actually enjoy a little versed, mixed with Demerol and a little Tito’s. Helps me relax.

[Myrddin]

I was given Amitiza as prep for a colonoscopy. It works by increasing fluid into the colon. Unfortunately, I'm in the under 1% of the population where Amitiza also causes fluid in the lungs. A few minutes after taking the capsule I started coughing up fluid. I was on my hands and knees for the next 8 hours coughing to keep my lungs clear. Just in time for a final bathroom visit, then off for the procedure. Never again.

[Mastador1]

What you mean is , not everyone takes the time to read the information that comes with their medication or has a pharmacist who warns them of interactions.

[Mastador1]

There is this thing called the internet, you know that thing Al Gore invented , and it is really easy to look up all your meds and check for not just interactions with things like grapefruit juice but with each other. I find it baffling that people would not do a few minutes of research into some pharmaceutical their doctor prescribed.

[Red Badger]

You’re talking about the same people who will not read an article on FR before posting a comment..............🙄

[mass55th]

I take Synthroid every morning. My doctor always told me not to drink citrus juices when I take it. Also, two of my youngest son’s heart medications warn against eating or drinking grapefruit or grapefruit juice.