‘Fountain Of Youth’ Protein Boosts Lifespan, Muscle, and Brain Power in Aging Mice — After Single Dose

Study Finds ^ | May 08, 2025 | Staff

[Red Badger]

I thought it was a cartoon character.......

[Ancesthntr]

This information about Klotho is not new. Do a search on YouTube, and you can find many videos on this going back more than a year. Here is one video that I like, and it even shows how to increase Klotho naturally (hint: exercise, emphasis on resistance training over endurance, but both work): https://youtu.be/4xQ1D-0vj4M?si=MbY8vZrchotAWeck

[SunkenCiv]

• NEWS 'Fountain Of Youth' Protein Boosts Lifespan, Muscle, and Brain Power in Aging Mice -- After Single Dose [05/08/2025]

  ---

• Melatonin shown to improve muscle energy efficiency, offering a potential therapy to combat 'diabesity' [03/13/2025]
• More evidence suggests regular consumption of melatonin can reduce chances of age-related macular degeneration [06/10/2024]
• Circadian therapy can optimize glymphatic clearance of concussion neurotoxins, accelerating recovery [10/08/2023]
• Study shows melatonin, commonly used to improve sleep, can aggravate bowel inflammation (Worsens colitis by hurting gut bacteria) [05/10/2023]
• Meta-analysis finds strong links between cluster headaches, migraines and circadian rhythm (Abnormally low melatonin) [03/29/2023]
• Use of melatonin linked to decreased self-harm in young people (About 50% less) [03/26/2023]
• Weighted blankets found to increase melatonin (30% higher) [10/03/2022]
• Higher dose of melatonin improved sleep in older adults (5 mg taken for 2 weeks = "Significant increase in total sleep time and sleep efficiency) [05/19/2022]
• Doctors want daylight saving time abolished. Here's why, and what you can do about it. [03/14/2022]
• Melatonin exacerbates asthma (Bloodstream amounts for asthmatics is okay) [12/10/2021]
• Finally, a Supplement That Actually Boosts Memory -- Many Already Take It for Better Sleep - melatonin [01/27/2021]
• Sulpiride and melatonin decrease tinnitus perception (shortened tile) [06/23/2018]
• New study suggests tart cherry juice can be a natural solution for insomnia [07/12/2010]
• EATING MELATONIN-RICH CHERRIES ARE ''NATURAL" WAY TO RESET YOUR BODY CLOCK WHEN CROSSING TIME ZONES [07/11/2009]
• Clock-gene variants linked to diabetes - Receptor for body-clock hormone connected to... [12/07/2008]
• Melatonin may save eyesight in inflammatory disease [11/23/2008]

[TheThirdRuffian]

“ They employed a delivery system using adeno-associated virus serotype 9 (AAV9)—a harmless virus modified to carry genetic material into cells. This allowed mice to continue producing the protein long-term after just one treatment”

Zombies. That how you get zombies.

[struggle]

>Gee, what could go wrong?

Yeah, let’s see a 40 year long-term test on this first.

[dfwgator]

I saw this movie...

[E. Pluribus Unum]

https://www.klotho.com/

[mac_truck]

The research team used gene therapy to deliver Klotho

No thanks...

[Dead Corpse]

No, klotho itself isn’t... What is new is using CRISPER to re-write a benign virus to get it into both the blood stream and into the brain so that cells can produce elevated amounts of it themselves...

Before was just supplementation and experiments.

[Colorado Doug]

Great! That’s all we need. Mice living longer. It’s hard enough to get rid of them as it is. Sheesh!

[mcatch22]

And all you need to do is inject the spliced virus into your brain. What could possibly go wrong?

[HKMk23]

This goes nowhere good.

https://www.sdfo.org/gj/stories/flowersforalgernon.pdf

P.P.S. Please if you get a chanse put some flowrs on Algernons grave in the
bak yard

[Red Badger]

Movie version:

https://en.wikipedia.org/wiki/Charly_(1968_film)

[Dead Corpse]

A lot... which is why we test it on animals first.

For better health as I age and a few more years of productive life... I’m willing to consign a few mice and monkey’s to an uncertain fate.

[Ancesthntr]

I would prefer at present to just go with the exercise route to increase Klotho. We know that exercise is good for us anyway, and maybe this is the underlying reason why. Although, just like turning the key means that your car engine starts, I don’t particularly care why exercise works, just that it does.

[BiteYourSelf]

And then there is the “Secret of NIMH”.🤔

[aimhigh]

There goes the solvency of the Social Security fund.