[tired&retired]

The high histamine causes inflamation in the lungs. In mine it caused the emphysema appearance found in pathology after the lung was removed. The inflamed lung allowed the cancer to form, attaching itself to the inflamed lung wall.

Keep in mind that when the stomach stretches it produces gastrin, a hormone, into the bloodstream. It then produces histamines, serotonin and somatotropin in the ECL cells.

One of histamine’s functions is to trigger acid release into the stomach in the parietal cells in the fundus (top) of the stomach for digestion.

This is how high histamine causes acid indigestion.

The back pressure on the billiary tree indicates there was also back pressure on the stomach for you, which stretches the stomach, which releases gastrin and thus increases histamines.

[Myrddin]

The Whipple removed my duodenum from pyloric valve to jejunum. The gall bladder was removed before the Whipple, but would have been removed as part of the Whipple. The resection dribbles pancreatic enzymes into the proximal end of the jejunum. A little further along, an anastamosis of the remaining bile duct is stitched to the jejunum. Bile dribbles continuously with no buffering from the gall bladder or Ampulla of Vater. A bit further down, the pylorus is stitched to the jejunum. Acidified food is free to discharge into the jejunum with little effective help to neutralize the acid from the bile dribble nor proper processing of fats with lipase, sugars with amylase or proteins with protease. It's a wonder that it works at all. Certainly less efficient. It takes 2000 calories to hold my weight steady where 1250 was sufficient in the past.

I'm unsure of how the histamine cycle operates after a Whipple. I am willing to give the DAO enzymes at test drive.