[Myrddin]

The Whipple removed my duodenum from pyloric valve to jejunum. The gall bladder was removed before the Whipple, but would have been removed as part of the Whipple. The resection dribbles pancreatic enzymes into the proximal end of the jejunum. A little further along, an anastamosis of the remaining bile duct is stitched to the jejunum. Bile dribbles continuously with no buffering from the gall bladder or Ampulla of Vater. A bit further down, the pylorus is stitched to the jejunum. Acidified food is free to discharge into the jejunum with little effective help to neutralize the acid from the bile dribble nor proper processing of fats with lipase, sugars with amylase or proteins with protease. It's a wonder that it works at all. Certainly less efficient. It takes 2000 calories to hold my weight steady where 1250 was sufficient in the past.

I'm unsure of how the histamine cycle operates after a Whipple. I am willing to give the DAO enzymes at test drive.

[tired&retired]

DAO could potentially decrease the acid in your stomach leading to better nutrient absorption.

With no duodenum, it really decreases your nutrient absorption, especially iron and calcium.

Ouch, that is quite a procedure. I lost the other end, part of transverse, descending and sigmoid to colon cancer. Had a colostomy for a year and then reconnection surgery. Amazing what they can do these days.

Here is an interesting research journal article that specifically mentions Diamine Oxidase Enzyme and nutrient absorption in the small intestine.

https://journals.physiology.org/doi/full/10.1152/ajpregu.1998.275.4.R969#:~:text=Nonfat%20nutrients%20appear%20to%20increase,maintenance%20of%20the%20mucosal%20barrier.