Posted on 04/15/2025 7:20:35 PM PDT by ConservativeMind
Why transplants are sometimes rejected and sometimes not depends largely on immune mechanisms. To help answer this question, researchers have analyzed the changes in the composition and function of the gut microbiome of kidney transplant patients who were included in the DZIF transplant cohort.
They discovered an altered signature in the gut microbiome that preceded transplant rejection.
In patients with chronic kidney disease, the composition of the gut microbiome is severely altered, resulting in lower concentrations of anti-inflammatory short-chain fatty acids (SCFA) and increased concentrations of pro-inflammatory metabolites from the microbiome.
In their study, researchers analyzed the changes in the composition and function of the gut microbiome of patients after kidney transplantation. They found changes in the gut microbiome that were already detectable before the transplant rejection reaction.
All patients analyzed in this study were part of the prospective cohort study of the DZIF, which was conducted at five German transplant centers in university hospitals. Together, these centers cover more than 20% of organ transplants in Germany.
It was noticeable that in patients who showed a rejection reaction, bacteria that typically occur in patients with advanced kidney failure, such as Fusobacterium and disease-associated genera such as Streptococcus, increased again. This was not the case in the other group studied, the "non-rejection group."
Overall, the analyses showed that the production potential of short-chain fatty acids in the stool is reduced before kidney rejection.
"Our results suggest that the microbiome plays an important role in how the immune system reacts after a kidney transplant. This observation can help to identify the risk of transplant rejection at an early stage or perhaps influence it therapeutically," summarize Holle and Reitmeir.
(Excerpt) Read more at medicalxpress.com ...
It is easy to help bacteria grow that produce short chain fatty acids. Soluble fiber is what these bacteria use, and they create butyrate, acetate, and propionate, from that fiber.
Beans, veggies, fruits, and even keto breads have soluble fiber to help.
Make sure you are getting at least 28 grams a day for women and 32-38 grams a day for men.
Inulin should be limited to less than 20 grams a day, to prevent other health issues.
It’s incredible what science is finding out about the gut and it’s connection to overall health.
Anyone who reads this who believes that you can ‘fix’ your gut in a few weeks with fiber intake...
...I have a bridge to sell.
More useless research.
Here’s a thought: Perhaps the microbiome is an indicator of OVERALL health.
Better, perhaps the microbiome is the CORE of body health.
Wowsers, right? /s
bkmk
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