Mark.
Soooo...it depends on your age, right? Not clear how much is too much.
[Nutrients, such as sugar or fat]
Excellent. I’ve been taking Nutrients for decades now.
Might check out Methylene Blue for NAD.
the book’s available at amazon or as a pdf, here’s the summary short form.
https://www.shortform.com/pdf/the-ultimate-guide-to-methylene-blue-pdf-mark-sloan
” . . .Methylene blue is gaining recognition as a potential therapy for disorders characterized by the progressive degeneration of the nervous system.
Sloan highlights the potential benefits of methylene blue in addressing cognitive dysfunction, particularly in conditions such as Alzheimer’s and Parkinson’s. He argues that current medical strategies for treating dementia fall short because they focus too much on genetics and fail to tackle the fundamental metabolic causes of the disease.
Methylene blue impedes the formation of tau aggregates associated with Alzheimer’s and prevents the build-up of amyloid deposits.
Sloan references a 2017 study which suggests that the primary factor behind the development of neurological conditions such as Alzheimer’s and Parkinson’s is the decline in brain metabolism associated with aging. Mark Sloan characterizes methylene blue as a formidable partner in the fight against dementia, largely because it significantly gathers in the brain’s tissues and has the ability to counteract the influence of nitric oxide.
Sloan addresses the common misconception that Alzheimer’s disease is caused by a shortage of acetylcholine. Mark Sloan presents a counterargument to the common perception by asserting that, as the brain ages, there is an actual increase in the concentration of acetylcholine, which could worsen the situation if these levels are further heightened. He proposes that the main approach to tackling Alzheimer’s should focus on lowering levels of acetylcholine.
Methylene blue enhances mental functions by elevating metabolic processes that generate energy in the brain.
In a pioneering study conducted in 2019, the author examines the impact of daily methylene blue administration in quantities of 8 to 16 milligrams on individuals diagnosed with Alzheimer’s disease. Research has indicated a significant decrease in cognitive decline, achieving an 85% reduction and effectively halting the progression of the disease.
Sloan describes Alzheimer’s as a condition primarily marked by two metabolic hurdles: a reduction in the brain’s glucose supply and impaired activity of mitochondrial complex IV. . .” . . .
bump for later
This has links to the free study that found a metabolite from NAD creation has some bad effects:
https://pubmed.ncbi.nlm.nih.gov/34580423/
Strangely, early nicotinamide riboside studies pointed to the creation of a large amount of 4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR) as a good indication that the supplementation was making what the body needed. Of course, there are multiple metabolites the body makes, but this bad one appears to come from an excess situation, from other items I read. It would seem better to time-release it, not have a big dose all at once.
Thanks, saving for later.
Ltr.
That’s my favorite sportsball team, the Nads. Our battle cry is ‘Go Nads!’