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Clinical trial: Repurposed drug improves outcomes for patients with severe COVID-19 pneumonia (Dornase alfa)
Medical Xpress / University College London / eLife ^ | July 16, 2024 | Joanna C. Porter et al

Posted on 07/25/2024 12:02:40 PM PDT by ConservativeMind

A drug commonly used to treat cystic fibrosis improved outcomes for patients with severe COVID-19 pneumonia and could be used to treat other respiratory infections, according to clinical trial results.

The study found that the drug dornase alfa reduced hyper-inflammation in COVID-19 pneumonia patients, which occurs when the body's immune system reacts too strongly and can lead to tissue damage and death.

Since the beginning of the COVID-19 pandemic, the proportion of SARS-CoV-2 infections that result in death has fallen. This is partly down to increased immunity from prior infection or vaccination, as well as improved treatments such as dexamethasone.

Researchers set out to assess whether dornase alfa could be used to improve outcomes for patients admitted to hospital with severe COVID-19 pneumonia who required oxygen.

Out of a total of 39 participants, 30 were randomized to receive twice-daily treatment with nebulized dornase alfa in addition to best available care (BAC) which included dexamethasone, with nine patients randomized to BAC only.

Patients treated with dornase alfa had a 33% reduction in systemic inflammation on top of the reduction provided by dexamethasone, as measured by C-reactive protein (CRP) levels in the blood over seven days or until they were discharged from hospital.

Patients treated with dornase alfa were also more likely to need less oxygen and be discharged sooner compared to patients who received BAC.

Professor Joanna Porter said, "Given that we observed a significant further reduction in C-reactive protein in patients who were already receiving dexamethasone, which also reduces inflammation, this trial is proof-of-concept that dornase alfa can be used to treat severe COVID-19 pneumonia. If we can help patients recover more quickly and get home sooner, this would be great.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: covid; dornasealpha
Dornase alfa is currently available and it would complement the use of the current best known ways to help people with serious COVID-19 pneumonia concerns.
1 posted on 07/25/2024 12:02:40 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 07/25/2024 12:03:08 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I’ll stick with mega doses of vitamin C.


3 posted on 07/25/2024 12:04:51 PM PDT by Leep (Still not convinced biden is alive.)
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To: ConservativeMind

WHAT? You mean OFF LABEL USE? That’s insane, the doctors should lose their licenses! Pharmacists should refuse to fill it!

What a difference 3 years makes. /s


4 posted on 07/25/2024 12:07:54 PM PDT by DesertRhino (2016 Star Wars, 2020 The Empire Strikes Back, 2024... RETURN OF THE JEDI. )
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To: DesertRhino

I’m guessing they have severe COVID-19-24.. because they took the jab multiple times.


5 posted on 07/25/2024 12:12:29 PM PDT by Leep (Still not convinced biden is alive.)
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To: null and void; aragorn; EnigmaticAnomaly; kalee; Kale; AZ .44 MAG; Baynative; bgill; bitt; ...

p


6 posted on 07/25/2024 12:13:43 PM PDT by bitt (<img src=' 'width=30%>)
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To: DesertRhino

Exactly: Off-label use! C’mon, people, you’re not a HORSE, stop it!!!

Meanwhile, the same people push Paxlovid, a much less effective substitute that just happens to cost orders of magnitude more than the 6 cents per tablet cost of Ivermectin, which has an expired patent. Let’s see.... profit of millions with sketchy results or no profits with successful results... the choice is obvious to the “medical profession” — go for the money.


7 posted on 07/25/2024 12:32:22 PM PDT by zipper (In their heart of hearts, all Democrats are communists)
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To: bitt
***Clinical trial: Repurposed drug improves outcomes for patients with severe COVID-19 pneumonia (Dornase alfa)***

I am not sure that the dormouse is the remedy I would seek?

8 posted on 07/25/2024 1:01:01 PM PDT by Bob Ireland (The Democrap Party is the enemy of freedom.They use all the seductions and deceits of the Bolshevics)
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To: ConservativeMind

I still have a hard time reading these types of articles without getting absolutely LIVID at the medical profession for essentially murdering one of my closest friends who trusted them. He was not vaccinated (we got legal help to fight that with our employer) and when he got Covid he was reluctant to take the Ivermectin and Hydroxychloroquine he had because it was so expensive (he had gotten it under the table). He took it too late. His last words to me were “Pray for me,” on his way to the hospital. He figured at least at the hospital they would do the right thing. They immediately put him on a ventilator, and three days later he was dead. Three years later I still miss him.


9 posted on 07/25/2024 3:14:01 PM PDT by scouter (As for me and my household... We will serve the LORD.)
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To: scouter
I recall how those drugs were $200 “from India.”

I am very sorry to hear of his situation. Yes, that would haunt me, too.

Someone here on Free Republic had a bad set of directions for handling COVID, and that person, and the spouse, I understand, both died. They had the original directions for HCQ or Ivermectin and took far less than was needed.

It became a stupid flame war, here, when it shouldn't have.

10 posted on 07/25/2024 4:21:25 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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