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Cholesterol-lowering drug slows progression of eye disease in people with diabetes: Clinical trial (fenofibrate)
Medical Xpress / University of Oxford / NEJM Evidence ^ | June 24, 2024 | David Preiss et al

Posted on 07/10/2024 2:15:11 PM PDT by ConservativeMind

The LENS trial has demonstrated that fenofibrate, a drug usually used to lower cholesterol, reduces the risk of progression of diabetic retinopathy by 27%.

Diabetes can cause damage to the small blood vessels at the back of the eye, a condition called diabetic retinopathy. Diabetic retinopathy is among the top five causes of visual loss worldwide.

Fenofibrate is a tablet that has been used to lower cholesterol for more than 30 years. Previous results from sub-studies of trials looking into treatments for heart disease had suggested that fenofibrate might be able to slow the progression of diabetic retinopathy but more conclusive results were needed.

The LENS (Lowering Events in Non-proliferative retinopathy in Scotland) trial compared the effects of fenofibrate with a placebo (dummy tablet) on the progression of retinopathy in 1,151 adults with type 1 or type 2 diabetes in Scotland as part of the national routine diabetic eye screening program. All of the participants had early to moderate diabetic retinopathy when they joined the trial.

The results showed that people who received fenofibrate had a 27% lower risk of needing to be referred for specialist care or treatment for diabetic retinopathy or maculopathy (a progressive eye disease that can lead to vision loss) over four years compared with people who were assigned to receive a placebo.

Treatment with fenofibrate was also associated with a lower risk of developing macular edema (swelling at the back of the eye) and a lower risk of requiring treatment for retinopathy compared to placebo, and the benefits of fenofibrate were similar in people with both type 1 and type 2 diabetes, and in people with both normal and impaired kidney function.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: diabetes
27% lower risk of diabetic retinopathy or maculopathy using fenofibrate.
1 posted on 07/10/2024 2:15:11 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

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2 posted on 07/10/2024 2:15:41 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Cholesterol lowering drugs i.e. statins are as big a hoax and effective as the covid jab.


3 posted on 07/10/2024 2:22:50 PM PDT by maddog55 (The only thing systemic in America is the left's hatred of it!)
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To: maddog55

Yes, and almost as dangerous. Type 2 diabetes is easily reversed in 99% of cases with dietary changes. Blaming cholesterol for heart disease and other maladies is like blaming firefighters for housefires.


4 posted on 07/10/2024 2:31:04 PM PDT by Blurb2350 (posted from my 1500-watt blow dryer)
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To: Blurb2350

👍👍👍


5 posted on 07/10/2024 2:49:02 PM PDT by maddog55 (The only thing systemic in America is the left's hatred of it!)
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To: ConservativeMind

Not for me, I treat my retinopathy the old fashioned way - I get a needle directly in my eye every six weeks, in fact thanks for the reminder I have an appointment later this morning.


6 posted on 07/11/2024 11:50:12 PM PDT by Sparky1776
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To: Sparky1776

My eye doctor doubled the dose so I don’t have to go as often. Think it’s working. To all who don’t know they numb the eye first and then put the needle in. It doesn’t suck as bad as one would think.


7 posted on 07/12/2024 12:08:33 AM PDT by Hillarys Gate Cult (“History doesn’t repeat itself but it often rhymes” - Possibly Mark Twain.)
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To: Hillarys Gate Cult

After about two years of going every 6 - 8 weeks (mostly 6) for injections he is going to do some tests to explore laser surgery for me. Not sure how I feel about that, if that doesn’t work ?


8 posted on 07/14/2024 4:21:23 PM PDT by Sparky1776
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To: Sparky1776

I Also have been getting the injections for a couple of years. I’m looking at full eye surgery if the injections don’t work. At least my vision hasn’t been getting worse.

Notice yo all. If your drivers license is coming up for renewal and your vision isn’t so good your eye doctor may be able to fill out a form and give you a control number for the corrective lenses. I went to the DMV and couldn’t see the bottom line clearly. I already had an eye appointment in a couple of weeks. The DMV told me about the form. My eye doctor took several tests and determined that yes, I can still drive. It seems the DMV doesn’t calibrate their machines that often. Whole process took about an extra month.


9 posted on 07/14/2024 5:01:46 PM PDT by Hillarys Gate Cult (“History doesn’t repeat itself but it often rhymes” - Possibly Mark Twain.)
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