https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856475/
Sucralose, A Synthetic Organochlorine Sweetener: Overview of Biological Issues
snip.... conclusions
4. Sucralose alters indigenous bacterial balance in the GIT. Sucralose (delivered as Splenda) reduced the number of indigenous bacteria in the GIT with significantly greater suppression for the generally beneficial anaerobes (e.g., lactobacilli, bifidobacteria) and with less inhibition for more detrimental bacteria (e.g., enterobacteria). Further, the numbers of total anaerobes did not return to baseline after a 3-mo recovery period (Abou-Donia et al., 2008). Alterations in the number and composition of bacteria were accompanied by elevation of fecal pH and histopathological changes in intestinal epithelial barrier. Given that alterations in gut microflora contribute to numerous medical conditions (Guarner and Malagelada, 2003; Hart et al., 2002; Turnbaugh and Gordon, 2009), further investigation of the impact of sucralose on gut microflora is warranted.
5. Numerous toxicological issues regarding long-term exposure to sucralose are unresolved. Several issues that warrant additional investigation to determine their clinical relevancy include potential damage to DNA (Sasaki et al., 2002), generation of chloropropanols during baking (Rahn and Yaylayan, 2010), and potential epigenetic alterations, particularly for the sucralose hydrolysis product 1,6-DCF which is an alkylating agent. The possibility of bioaccumulation of sucralose and/or its metabolites in the presence and absence of medications has not yet been studied. The health effects of co-administration of sucralose with the taste enhancer ADTP are not known.
It’s probably the chlorine ions that are part of the sucralose. Essentially “BLEACH”................