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New study reveals Viagra improves brain blood flow and could help prevent dementia
Medical Xpress / University of Oxford / Circulation Research ^ | June 7, 2024 | Alastair J.S. Webb et al

Posted on 06/11/2024 2:42:13 PM PDT by ConservativeMind

A new trial reveals that sildenafil, commonly known as Viagra, enhances blood flow to the brain and improves the function of brain blood vessels in patients at a heightened risk of vascular dementia.

This study marks a potentially pivotal step in the fight against this debilitating condition.

Dr. Alastair Webb said, "This is the first trial to show that sildenafil gets into the blood vessels in the brain in people with this condition, improving blood flow and how responsive these blood vessels are.

The significance of this research lies in its potential to transform the treatment and prevention of vascular dementia, which currently lacks specific therapies.

Chronic damage to the small blood vessels in the brain is not only the leading cause of vascular dementia but also contributes to 30% of strokes and 80% of brain bleeds. High blood pressure, reduced blood flow to the brain, and impaired blood vessel function exacerbate these conditions, making the findings of this trial particularly crucial.

The OxHARP trial was a meticulously designed double-blind, placebo-controlled study involving 75 participants who had experienced a minor stroke and showed signs of mild to moderate small vessel disease. Each participant received sildenafil, a placebo, and cilostazol (a similar drug) over three-week periods in a randomized order. The study employed cardiovascular physiology tests, ultrasound, and functional MRI scans to evaluate the drugs' effects.

Key findings include:

- Sildenafil increased blood flow in both large and small brain vessels as measured by ultrasound and MRI scans.

- Sildenafil enhanced the blood flow response to carbon dioxide, indicating improved cerebrovascular function.

- Both sildenafil and cilostazol lowered blood vessel resistance in the brain. Sildenafil caused fewer side effects compared to cilostazol, particularly with less incidence of diarrhea.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: dementia; hh2; highbloodpressure; sildenafil; stroke; viagra
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To: ConservativeMind
Get ready for blue-tinted vision, a common side effect of sildenafil. I experience it. It's weird and disconcerting.
In rare cases, users may experience an odd side effect: changes in eyesight, including blue-tinted vision, that last for several weeks. The report, published Feb. 7, 2020 in the journal Frontiers in Neurology, describes the cases of 17 men who visited a hospital in Turkey with vision problems that persisted for more than 24 hours after they'd taken sildenafil.

The problems reported included blurred vision, sensitivity to light, reduced eyesight and changes to color perception, including "intensely blue-colored vision," a side effect known as cyanopsia. Those with cyanopsia also reported "red-green colorblindness," in which red and green hues appear to be brownish, the report said. None of the patients had a history of eye disease or colorblindness.

While it's known that sildenafil can cause temporary vision changes, including blurred vision and cyanopsia, these side effects typically disappear within 3 to 5 hours. Persistent vision changes, like those seen in this report, are much rarer. Fortunately, the vision problems for all of the men described in this report went away after 21 days.


21 posted on 06/11/2024 3:17:27 PM PDT by ProtectOurFreedom (“When exposing a crime is treated like a crime, you are being ruled by criminals” – Edward Snowden)
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To: ConservativeMind

If you have been focused on the same math problem for four hours then take a break.


22 posted on 06/11/2024 3:19:02 PM PDT by ansel12 ((NATO warrior under Reagan, and RA under Nixon, bemoaning the pro-Russians from Vietnam to Ukraine.))
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To: wally_bert

A Federally Funded Study is needed.

Or we could just go with better to be safe than sorry.


23 posted on 06/11/2024 3:21:56 PM PDT by smokingfrog ( sleep with one eye open (<o> --- )
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To: ConservativeMind

Well, wasn’t it initially developed as a vasodilator to keep the blood flowing?

While in Afghanistan, medics told me it was in their box of drugs and could be used to treat altitude sickness.


24 posted on 06/11/2024 3:22:23 PM PDT by qaz123
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To: TheThirdRuffian

Holy cow you’re right! I remember that! My brother gave me a pill last year and it was just a complete bad reaction, I had a ripping headache and my face was red as hell. It was stupid though to take any prescription drug without seeing a doctor first. But it felt as it my entire body was a penis lol lol Seriously, no joke,...Oh yeah the blood rushed in alright, and made me feel like my entire body was going to explode from the pressure, it was not fun.


25 posted on 06/11/2024 3:22:42 PM PDT by GrandJediMasterYoda (As long as Hillary Clinton remains free, the USA will never have equal justice under the law)
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To: ConservativeMind
Just one little, teensy weensy problem, from 2022...

A Systematic Review of Sildenafil Mortality Through the Years

Course if you croak from a cardiac issue, hey, at least you won't get dementia!

Nice try Deep State.

26 posted on 06/11/2024 3:23:10 PM PDT by mewzilla (Never give up; never surrender!)
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To: bleach

Keeps ‘em from rolling over in bed, too.


27 posted on 06/11/2024 3:23:31 PM PDT by bigbob
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To: GrandJediMasterYoda

See my reply #26.


28 posted on 06/11/2024 3:23:54 PM PDT by mewzilla (Never give up; never surrender!)
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To: smokingfrog

“Viagra, enhances blood flow to the brain and improves the function of brain blood vessels...”

My wife insists she is the expert on where my brain is located.


29 posted on 06/11/2024 3:24:26 PM PDT by CTyank
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To: qaz123

Top Gear demonstrated something similar.


30 posted on 06/11/2024 3:28:19 PM PDT by wally_bert (I cannot be sure for certain, but in my personal opinion I am certain that I am not sure..)
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To: ConservativeMind

I’ve read that Viagra can cause blindness. The sudden blood pressure can burst the tiny capillaries in the retina.


31 posted on 06/11/2024 3:31:16 PM PDT by Angelino97
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To: ProtectOurFreedom
Get ready for blue-tinted vision, a common side effect of sildenafil. I experience it. It's weird and disconcerting.

But the Spice must flow!


32 posted on 06/11/2024 3:34:00 PM PDT by Yo-Yo (Is the /Sarc tag really necessary? Pray for President Biden: Psalm 109:8)
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To: ConservativeMind

“New study reveals Viagra improves brain blood flow and could help prevent dementia”

It certainly helps one of the brains..,the one with no conscience unfortunately.


33 posted on 06/11/2024 3:42:29 PM PDT by Bonemaker (invictus maneo)
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To: ConservativeMind

good to know in an erection year.


34 posted on 06/11/2024 3:47:40 PM PDT by Qwapisking ("IF the Second goes first the First goes second" L.Star )
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To: ConservativeMind

OMG...like a bad joke...little head and big head ARE connected....


35 posted on 06/11/2024 3:47:57 PM PDT by Adder (End fascism...defeat all Democrats.)
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To: ConservativeMind

Traitor Joe is a demented d!ckhead, so just inject it directly into his brain.


36 posted on 06/11/2024 3:48:51 PM PDT by rfp1234 (E Porcibus Unum )
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To: GrandJediMasterYoda

How many hundreds of milligrams did you take? If you need more than 50 mg you’ve got bigger problems! Dangerous to take it with nitrogen drugs.


37 posted on 06/11/2024 3:49:34 PM PDT by Bonemaker (invictus maneo)
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To: ConservativeMind

Wahtever you do, don’t take Viagra at the same time as Rogain. It will make your hair stand on end.


38 posted on 06/11/2024 3:53:03 PM PDT by Jeff Chandler (THE ISSUE IS NEVER THE ISSUE. THE REVOLUTION IS THE ISSUE.)
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To: qaz123
could be used to treat altitude sickness

Mile High Club?

39 posted on 06/11/2024 3:54:41 PM PDT by Jeff Chandler (THE ISSUE IS NEVER THE ISSUE. THE REVOLUTION IS THE ISSUE.)
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To: ConservativeMind

Just what the potato needs.


40 posted on 06/11/2024 3:55:05 PM PDT by HIDEK6 (God bless Donald Trump)
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