Posted on 06/10/2024 9:58:12 PM PDT by ConservativeMind
A team of researchers has discovered that a common anti-inflammatory drug, mesalamine, can replace the work of good bacteria in fighting the nasty fungus Candida albicans in the gut.
C. albicans, or candida, is known to cause yeast infections.
The researchers found that this fungus can't grow without an oxygen supply. Their study showed that the drug can maintain a low oxygen (hypoxia) environment that prevents fungal bloom in the gut.
When the body's immunity goes down due to cancer or chemotherapy, the fungus may grow beyond the colon and spread throughout the body. In such cases, the patient develops invasive candidiasis.
"Invasive candidiasis is a potentially deadly infection with a mortality rate of around 50%. That's even with the best available treatment," explained Andreas Bäumler.
Patients with leukemia and other blood cancers may need to take antibiotics. This use may cause an imbalance in the gut's microbial community. It reduces Clostridia, a group of bacteria that promotes resistance to fungi colonization in the gut. With less Clostridia, C. albicans grows and colonizes in the tract.
They first colonized germ-free mice with Candida to see what the fungus consumed to bloom. They realized that Candida really liked simple sugars, similar to those found in high-sugar diets. Then, they tested its growth in a petri dish. They placed Candida with simple sugars in an aerobic (with oxygen) setting, and the fungi bloomed.
The team explored 5-aminosalicylic acid (5-ASA) as a safer way to control C. albicans in the gut. 5-ASA, also known as mesalamine, is an anti-inflammatory drug. It is used to treat inflammatory bowel diseases (IBD).
The team tested 5-ASA in mice treated with antibiotics. They found that the drug could replace the work of probiotics by preventing oxygen in the colon and C. albicans from expanding in the gut.
(Excerpt) Read more at medicalxpress.com ...
This pro-pharmacological research is FAR from new and totally unnecessary:
If you eradicate the gut infection, your immune system takes care of the rest.
Ask me how I know (a lifetime of athlete’s foot and jock itch naturally abated once I cured my infection).
Drugs are not the answer, but they sure want you to believe it while they gaslight you about revelations in their so-called ‘knowledge’ about the gut...
Thats because your health begins in your gut. :)
Yes, and flooding it with drugs is not the answer.
Side effects of Mesalamine:
Adverse Effects
Patients tolerate most 5-ASA formulations. However, adverse effects may include nausea, gastrointestinal upset, abdominal pain, headaches, nasopharyngitis, rash, arthralgias, agranulocytosis, aplastic anemia, myalgias, bone marrow suppression, oligospermia, hematuria, and cholestatic hepatitis. Renal impairment, including interstitial nephritis, nephrotic syndrome, and renal failure, can be seen and must be carefully monitored before initiating treatment and during treatment.[10][21]
Hypersensitivity reactions are also common, and there have been reports of pericarditis, myocarditis, hepatitis, nephritis, pneumonitis, and hematology-associated reactions. Patients may also be intolerant to 4-ASA, which causes symptoms such as cramping, headache, fever, malaise, pruritis, rash, and abdominal pain. Treatment must be discontinued if such issues occur.[22][23] Mesalaine-induced myocarditis has been reported, which may require discontinuation of 4-ASA.[24][25]
Drug-Drug Interactions
Antacids: Antacids may disrupt the pH-dependent formulations of 5-ASA. This condition can result in premature release and a decrease in the therapeutic effect of 5-ASA.[26]
Heparin: 5-ASA can enhance the pharmacologic effects of heparin and subsequently increase the risk of bleeding or bruising.[27]
Cardiac glycosides: 5-ASA may decrease the concentration of cardiac glycosides in the blood.[28]
Myelosuppressive agents (eg, mercaptopurine): Increase bone marrow suppression risk.[29]
H2 receptor blocker: H2 receptor blockers may increase gastrointestinal pH, cause premature release of 5-ASA, and decrease the therapeutic effect.
NSAIDs: Concomitant use of NSAIDs with 5-ASA increases the risk of nephrotoxicity.
Thiopurine analogs (eg, mercaptopurine): Interaction with 5-ASA may decrease the metabolism of thiopurine analogs.[29]
Proton pump inhibitors: Proton pump inhibitors may increase gastrointestinal pH, induce premature release of 5-ASA, and decrease the therapeutic effect.
Varicella vaccine: Increases risk of Reye syndrome and may enhance the toxic effects of these vaccines.[10]
https://www.ncbi.nlm.nih.gov/books/NBK551714/
So what food contains it? Where can you buy it?
Let’s not forget that, like most of the “miracle drugs that they keep pushing for anything and everything:
Mesalamine may cause serious side effects. Stop using mesalamine and call your doctor at once if you have:
severe stomach pain, stomach cramping, bloody diarrhea;
fever, headache, general ill feeling;
rash, itching, eye redness;
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
low white blood cell counts—fever, chills, mouth sores, skin sores, sore throat, cough, feeling light-headed, trouble breathing;
signs of a kidney stone—severe pain in your side and back, frequent need to urinate, foul-smelling urine, dark or cloudy urine;
kidney problems—increased or decreased urination, swelling, weight gain; or
liver problems—loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Low white blood cell counts may be more likely in older adults.
Ok. I’m asking how you know? What did you do to restore your gut health that eliminated the atletes foot, etc?.
Ironically, those words still ring in my ears, echoing the very last time I held a public meeting in outreach with people seeking help for their health conditions.
The second (actually, 3rd) interim title of my book - now merely the name of a chapter - was "How to Achieve a Healing State." You won't find it on the web as I long ago abandoned social media and deleted all reference.
As I attempted to answer that question - to literal pounding on the table as she screamed the question 2 more times in my face - in mere seconds the trajectory of what I'd thought might be my retirement went completely off the rails with an epiphany and I abandoned my book project...at least for the ensuing 10 or so years.
If you noticed - and trust me: I know why you missed it - I answered your question in my comment. I'll give more detail, provided that you understand it's not a solution.
Rather, it's a demonstration that it CAN be done. But since I am NOT retired, I must now leave and be slave to the establishment.../s
“An anti-inflammatory curbs spread of fungi causing serious blood infections (Mesalamine)”
Or said another way with the same meaning,
(Mesalamine), An anti-inflammatory, causing serious blood infections.
How about...
An anti-inflammatory (Mesalamine), prevents serious blood infections by curbing the spread of fungi.
If you are not greatly immune compromised, the write up directly describes that three things are the problem. First, simple sugars in your gut. Second, unexpected oxygen in your gut. Third, good bacteria do not seem to be in your gut, any longer (could be from antibiotics or simply eating in such a way as to eliminate or reduce good bacteria populations to a level they can't help).
Step one would be to stop eating things that become, or are, simple sugars. Step two surrounds the oxygen issue, which seems to be from missing populations of gut bacteria that otherwise help pull out oxygen from the gut.
There is a picture at the website link. It states several times that butyrate is produced by Clostridia bacteria is a key, here. Note, I haven't read the study, but this makes sense, to me.
I have previously posted threads about how soluble fiber increases three short chain fatty acids, acetate, propionate, and butyrate. It does this by growing populations of bacteria that are still there. Given enough soluble fiber over a month or more, those populations should be providing you each needed substance, with whatever butyrate made preventing the candida issue.
Do note you may need a probiotic or kefir to provide bacteria you may not have at this time, but to better know this, the easy way is to see if you still have issues with candida in your gut. The more costly way to identify an issue is to have a poo sample analysis, which can cost a few hundred dollars, but can be ordered online.
This is how I would make it all practical, and my wife and I have done this, without intending to address any candida concern.
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