Posted on 06/08/2024 8:01:42 PM PDT by ConservativeMind
Hyperuricemia (HU) is diagnosed when the levels of urate in the blood exceed 420 μmol/L, the saturated concentration of urate. In mainland China, the prevalence of HU exceeds 17.7% in the adult population, affecting over 185 million individuals.
HU has become the fourth most common chronic metabolic condition in China, following hyperlipidemia, hyperglycemia, and hypertension. HU not only triggers gout but also increases the risk of various metabolic diseases, including obesity, diabetes, cardiovascular and cerebrovascular diseases, hypertension, and kidney disease.
Among the 25 million gout patients in China, more than half exhibit abnormal blood lipid levels. Although preliminary analysis suggests that hypertriglyceridemia may be a causal factor for HU, the underlying mechanism has remained elusive.
Recently, Professor Yin Huiyong's team unveiled a mechanism by which fatty acid oxidation induces hepatic urate synthesis and HU.
They reported that in metabolic disorders, such as hypertriglyceridemia and non-alcoholic fatty liver disease, hepatic fatty acid oxidation induces activation of hypoxia-inducible factor-1α (HIF-1α), which transcriptionally activates the urate synthesis pathway involving xanthine dehydrogenase (XDH) and cytosolic 5´-nucleotidase II (NT5C2). This mechanism represents the first discovery of a bridging role between lipid metabolism and purine metabolism pathways in metabolic diseases, offering potential strategies for the prevention and treatment of hyperlipidemia and HU.
(Excerpt) Read more at medicalxpress.com ...
Interestingly, your high urate/gout condition can encourage high blood pressure and diabetes.
From a separate study, I want to note that high blood insulin can cause high blood pressure in diabetics, due to a problem high insulin causes in which it blocks nitric oxide release, which is a common way our bodies lower blood pressure.
I only add that because there are sometime chains of consequences that by targeting closer to the root cause, you can mitigate most all the succeeding issues.
Unfortunately, it’s hard to know which problem was is the actual start of your chain of consequences.
So, China is developing significant numbers of diseases of affluence?
HU not only triggers gout but also increases the risk of various metabolic diseases, including .....kidney disease.
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Hyperuricemia is too much uric acid in the blood. Medical science, including this article, blame the liver, the organ which produces the uric acid, and not the kidneys, the organ responsible for clearing the uric acid. I suspect that different patients have different causes.
If you say so....
Including CoupFlu vaxxes.
There have been a number of papers published on it, both in kids and adults.
What a coinkydink!
A thought...
With CoupFlu vaxx uptake so low, unless some are still getting boosted, if some of this damage is occurring months and/or years after last CoupFlu vaxx...
Holy bleep...
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