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Low-dose aspirin reduces inflammation caused by sleep loss
Medical Xpress / American Academy of Sleep Medicine / SLEEP ^ | June 3, 2024 | Larissa Engert et al

Posted on 06/06/2024 8:58:56 PM PDT by ConservativeMind

A new study found low-dose acetylsalicylic acid, also known as aspirin, can reduce inflammatory responses to sleep restriction.

Results show that compared with placebo, preemptive administration of low-dose aspirin during sleep restriction reduced pro-inflammatory responses. Specifically, aspirin reduced interleukin-6 expression and COX-1/COX-2 double positive cells in lipopolysaccharide-stimulated monocytes, as well as C-reactive protein serum levels.

"The novelty of this study is that it investigated whether we can pharmacologically reduce the inflammatory consequences of sleep restriction," said Larissa Engert.

"We used a non-steroidal, anti-inflammatory drug because it has been shown to affect specific inflammatory pathways, which were previously shown to be dysregulated by experimental sleep restriction or sleep disturbances."

The researchers collected data from 46 healthy adults in a randomized placebo-controlled crossover trial with three protocols—sleep restriction/aspirin, sleep restriction/placebo, and control sleep/placebo—each consisting of a 14-day at-home phase followed by an 11-day in-hospital stay.

In the sleep restriction/aspirin condition, participants took low-dose aspirin during the at-home phase and in-hospital stay. Each in-hospital stay started with two nights of an eight-hour sleep opportunity. Then, under the sleep restriction conditions, participants were exposed to five nights of a four-hour sleep opportunity, followed by three nights of recovery sleep.

The control sleep condition provided an eight-hour sleep opportunity throughout the in-hospital stay. Sleep and immunologic measures were assessed at baseline and various points throughout the study.

The data also reveal that the aspirin-induced reduction of inflammatory pathway activity in sleep-restricted participants was paralleled by decreased wake after sleep onset and increased sleep efficiency during recovery sleep, Engert noted.

"These findings show it is possible to blunt inflammatory pathways activated by sleep restriction through preemptive administration of low-dose aspirin.

"Such therapeutics could complement behavioral sleep improvement therapies to better prevent or control inflammation and its consequences in those experiencing periods of sleep deficiency," Engert said.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: aspirin; inflammation
A small amount of aspirin before sleep deprivation helps counter the inflammation a lack of sleep brings to you.

It doesn’t make you more alert, however,

1 posted on 06/06/2024 8:58:56 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 06/06/2024 8:59:17 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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sleep??? what exactly is this sleep you speak of...


3 posted on 06/06/2024 9:13:34 PM PDT by Chode (there is no fall back position, there's no rally point, there is no LZ... we're on our own. #FJB)
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To: Chode
> sleep??? what exactly is this sleep you speak of...

I've heard of it. My parents told me stories about it when I was quite young. Myths, actually.

But as I got older I came to understand that it's merely an ephemeral state of consciousness in which one is somewhat less productive than normal.

4 posted on 06/06/2024 9:23:13 PM PDT by dayglored (Strange Women Lying In Ponds Distributing Swords! Arthur Pendragon in 2024)
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To: dayglored

OH Yeah...


5 posted on 06/06/2024 9:26:48 PM PDT by Chode (there is no fall back position, there's no rally point, there is no LZ... we're on our own. #FJB)
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To: Chode

“sleep??? what exactly is this sleep you speak of...”
^
It’s that period when your Smartphone falls from your hands for a couple of hours.


6 posted on 06/06/2024 9:28:12 PM PDT by Does so ( 🇺🇦....We are in the later stages of a Communist takeover...)
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To: Does so

lol...


7 posted on 06/06/2024 9:30:02 PM PDT by Chode (there is no fall back position, there's no rally point, there is no LZ... we're on our own. #FJB)
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