Posted on 06/05/2024 6:47:58 PM PDT by ConservativeMind
Physician-scientists show that carpal tunnel syndrome preceded the development of cardiac amyloidosis by 10–15 years and individuals with carpal tunnel syndrome were at a high risk of developing cardiac amyloidosis.
"Cardiac amyloidosis may be responsible for one in 10 cases of heart failure," said Naman S. Shetty, M.D.
"Early identification of cardiac amyloidosis may allow the initiation of disease-modifying therapeutic agents."
"We found that individuals with carpal tunnel syndrome exhibited a 13 percent higher risk of developing heart failure and a threefold higher risk of amyloidosis compared to those without carpal tunnel syndrome," Shetty said.
Shetty says the development of carpal tunnel syndrome before developing cardiac amyloidosis may be attributed to the disease process in amyloidosis. The deposition of protein fragments in various tissues leads to the manifestations of amyloidosis.
Shetty notes that the carpal tunnel is a tight space in the wrist and the deposition of even a small amount of protein fragments leads to the development of symptoms. However, a large amount of protein deposition in the heart is required for the alteration of the function of the heart and the development of cardiac symptoms.
Pankaj Arora, M.D., explains that cardiac amyloidosis is broadly classified as wild-type, meaning it has no identifiable genetic mutation, or hereditary, meaning it is caused by a genetic mutation in the TTR gene.
"The study found that carriers of a TTR mutation have a roughly 40 percent higher risk of developing carpal tunnel syndrome, with the risk increasing notably around the age of 50-60 years.
"Our previous work showed that the risk of heart failure in individuals carrying a TTR mutation increased at nearly 75 years of age."
Arora notes that genetic testing for TTR variants may prove to be a feasible strategy for screening. 3–4% of Black individuals carry a genetic variant.
(Excerpt) Read more at medicalxpress.com ...
It’s interesting to be able to leverage a problem to prevent a much worse one.
True story:
I developed CTS first in my right hand and later in my left, probably due to my keyboard use at the time (so I thought).
Over the ensuing 10 years, I completely reversed the CTS in both hands, later - oddly - developing CTS only in my left hand (no risk factors). This happened to coincide with other issues which developed after the virus.
I’ve since remedied all CTS, all by managing inflammation.
FWIW
There are stretching exercises for carpal tunnel on the web.
I think mine was strictly because of all the sewing I do. Not stretching the ligaments and/or tendons enough plays a role in it.
Stretching never helped me. It was always just temporary (as in seconds).
I can’t tell you how nice it is not to look like a crazy person repetitively shaking my hand(s) to relieve the tingling (as I did for a number of years).
I don’t miss that sensation.
I hear you. I had the surgery and it was the best decision I ever made.
I know others who had the surgery; most of them didn’t regret it (a couple had complications; one was never able to work again).
You can understand why I was resistant to the procedure, but I’m pleased that it was successful for you.
I do think that the point of my original comment was missed, however.
There is prolific research suggestive of the relationship between inflammation and CVD. Plus the fact that at its core amyloids form primarily due to vascular disease.
But there’s too damned much money in ‘medicine’ treating CVD and vascular disease in general - to state nothing of big pharma - and I fully expect to be room temperature long before anything changes.
However I have never seen heart amyloidosis.
So I question the article.
Walking and doing various things will get rid of most pain.
Get a treadmill and or a stepper for indoor exercise.
When I started using computers and sitting all day at my job I learned to get a good chair and a mouse that fit my hand and a keyboard without the keypad on the right side as it was too wide for me. Also adjusting the monitor height.
My first mouse was from a Packard Bell computer and it was shaped like a mouse. High round that fit in the palm and the buttons were lower in front.
My hand soon hurt from using it.
https://www.ebay.com/itm/394940175739
I bought a VARI adjustable height desk 3 years ago. I raise and lower it all thru the day when using the desk and looking at the computer screen.
30” deep and 48” wide.
Many companies now offer one and a lot cheaper. You want the 30” deep one so you can move the monitor back away from you. $200 and up.
https://www.amazon.com/s?k=standing+desk&i=garden&ref=nb_sb_noss
Stretching fixed issues with pinched nerves from neck down thru left arm to fingers. Lower back stretches for Sciatica and or herniated disc and also issues with exercise that caused pain in both upper arms.
Get a Pull up bar rack so you can hang from it and use your weight to straighten you out.
https://www.amazon.com/DlandHome-Station-Equipment-Strength-Training/dp/B0851947FW?th=1&psc=1
This tool is great for fixing hand and arm pain.
Via Prohands
https://www.amazon.com/PROHANDS-Spring-Loaded-Finger-Piston-Medium-Tension/dp/B000Y04WZA?ref_=ast_sto_dp&th=1&psc=1
Meanwhile, guess what else could increase your risk, from last year...
COVID-19 Infection and Vaccination and Its Relation to Amyloidosis: What Do We Know Currently?
Scroll way down for the part of vaccination. They buried the lede.
BS. had CP for 30 years now.
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