Posted on 04/17/2024 5:16:44 PM PDT by DoodleBob
Wednesday, GSK plc (NYSE:GSK) revealed data from the ZOSTER-049 long-term follow-up phase 3 trial, which followed participants for up to approximately 11 years following initial vaccination with Shingrix (Recombinant Zoster Vaccine or RZV).
The final trial data demonstrate that RZV has maintained efficacy against shingles in adults over 50 for over a decade.
ZOSTER-049 included over 7,000 participants.
The results from ZOSTER-049, an extension from two phase 3 clinical trials in adults aged 50 and over (ZOE-50 and ZOE-70), include:
79.7% vaccine efficacy (VE) in adults aged ≥50 cumulatively from year six to year 11 after vaccination.
82.0% VE in adults ≥50 at year 11, showing VE remains high each year after vaccination.
73.1% VE in adults aged ≥70 cumulatively from six to 11 years after vaccination, showing high VE rates across all age groups.
Javier Díez-Domingo, Principal Investigator, said: “These final data demonstrate continued protection over more than a decade with high efficacy maintained in both the 50+ and 70+ age groups.”
GSK said it will continue to evaluate long-term data and conduct real-world evidence studies on vaccine efficacy, immunogenicity, and safety across indicated populations.
No new safety concerns were identified during the follow-up period in ZOSTER-049.
The investigators considered no serious adverse events causally related to RZV vaccination.
In adults aged 50 years and over, the most frequently reported adverse reactions with RZV are pain at the injection site, myalgia, fatigue, and headache. Most of these reactions were mild to moderate in intensity and generally lasted less than three days.
(Excerpt) Read more at msn.com ...
"Antivaxxer" - That's what I get called when they find I didn't get the Covid vax - then I tell them I got the Shingles vax after seeing three years worth of good data. "Oh"
Very informative. Thank you.
Had 10 days of shingles on my face, followed by years of post-herpetic neuralgia. The worst pain ever for weeks, screaming while being tortured for 5 minutes every few hours as PHN waves would reappear, until my neurologist prescribed gabapentin and amitriptyline. I took those for a few months until the waves went away.
Still feel the effects 9 years later, even as I’m sitting here writing this. Took the Shingrix shot later, happily.
With the Covid shots, the human race is part of that clinical trial. And we are only 3 years into it.
Nope. Not taking their word for it, thanks.
I’ll wait a while.
Dittos!
Hubby woke up with what looked to be shingles one morning.
Got him to the doc. Doc gave him a recommended antiviral.
It worked very well because he got in within 24 hours of onset.
He hasn’t had another flare.
And according to the doc, some folks who get shingles are once and done.
Just some food for thought.
I’m not minimizing shingles, BTW. A couple of other loved ones had terrible, repeated flares.
But that was before the oral antivirals were available.
If you were in grade school, as I was, during the polio epidemic, it’s very likely that your parents would have given you the polio vaccine. For starters, it was eaten as a food as a purple dye on a sugar cube, not an injection.
At the time, we children couldn’t go to any summer gathering such as fairs, carnivals, or even swimming holes, for fear of polio. It was a terrible disease as it paralyzed body muscles. Those who had paralyzed breathing were relegated to a lifetime in an “iron lung”, a coffin like device with only your head sticking out, that breathed for you. Others had paralyzed arms or legs, or half faces, along with atrophied muscles making them look like moving skeletons.
The polio vaccine made childhood fun again. It also led to ‘herd immunity’ that removed polio from the country, though it may be returning now with Biden’s hoards of unvaccinated illegal immigrants.
I already had shingles. Its not the end of the world. Keep your immune system strong and you won’t get them. Vaccines aren’t the answer for everything in life.
The mix of first-hand accounts on this thread was helpful.
My point was a vaccine that’s 70-80% effective 10+ years later is the Gold Standard. That how America used to roll.
The Covid nonsense, calling something a VACCINE that was an elixer that had a 12-week trial using new technology, and then treating skeptics like war criminals, was gaslighting at best.
over a year later, I still have a sizable scab cluster from shingles on my back. a doctor visit a couple weeks ago I asked about it... She said go and get the vaccine. They can come back. no words at all to my question, how much longer will this scab remain/how do I get rid of it!?? (itches constantaly!!)
Any of you know how to get rid of it??
I’ve had both the older shingles vaccine and the the first shot of the more recent Shingrex (more recent but not “new”; definitely more effective).
Have you been to a dermatologist? Cryotherapy is sometimes an option to “calm things down”, administered at a lower intensity than when used to remove moles, etc. And, of course, hydrocortisone in the meantime. And select a hydrocortisone lotion that includes various “natural” anti-pruritic ingredients. And for really acute itching you can try to numb it with pramoxine. dibucaine, or lidocaine. But don’t overdue the “caines” — you can end up with “reverse-numbing” or hypersensitization.
Overdo
Data is good.
I will add that dibucaine 1% ointment, usually marketed for hemorrhoids, is really good for general anti-itch and doesn’t normally irritate or cause any sort of side effect. Search on Amazon.
btt!
Agree. All vaccines are not equal. A vaccine using a dead virus and no mrna that actually inoculated you against a disease is different from the “covid vaccine” which isn’t a vaccine at all. Its a poison depopulation tool.
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