Posted on 04/06/2024 8:12:45 AM PDT by ConservativeMind
Parkinson's disease (PD) is a common neurodegenerative disease that affects millions worldwide. Now, a groundbreaking clinical study has demonstrated the potential of fecal microbiota transplantation (FMT) to improve symptoms in patients with PD.
Motoric symptoms, such as balance problems, stiffness, and the characteristic tremor, are the best known and almost always the reason for the eventual diagnosis. However, non-motor symptoms, such as loss of smell, constipation, and REM sleep disturbances, often develop up to 20 years before diagnosis in a large number of people with the disease.
In Parkinson's disease, a protein called alpha-synuclein misfolds and clumps together. Those clumps then damage dopamine-producing nerve cells in the brain, which leads to the typical Parkinson's symptoms.
The protein clumps are believed to be formed in the gut wall at a very early stage of the disease, from which they reach the brain cells via the vagus nerve, which connects the gut and the brain. This process can be influenced by gut bacteria.
Patients with Parkinson's often have an altered gut microbiome compared to healthy individuals and they often show more (intestinal) inflammation and a disrupted intestinal barrier.
The clinical study showed after 12 months, the actively treated group showed significantly more improvement in motor symptoms compared to the placebo group.
"Our results are really encouraging!" says Dr. Arnout Bruggeman. "After twelve months, participants who received the healthy donor stool transplant showed a significant improvement in their motor score, the most important measure for Parkinson's symptoms."
The improvement in motor symptoms became even more pronounced between the sixth and twelfth month after the transplant, suggesting a potential long-lasting effect. Additionally, participants had less from constipation, a frequent and bothersome symptom for many people with Parkinson's disease. More research is needed to determine whether this treatment also slows the progression of the disease.
(Excerpt) Read more at medicalxpress.com ...
It appears gut bacteria are a prime cause, and solution to, at least this indication of Parkinson’s.
Perhaps the best way to help, outside of getting a fecal transplant, is to use fermented foods and beverages, prebiotic soluble fiber, and probiotic supplements, along with a lower carb-type diet and exercise, with what is becoming known.
Who would have thought gut germs were so helpful?
Interesting.
How to choose, how to choose?
Our entire health is tied to our gut.
HA HA!
I wouldn’t want to do the transplanting, but God bless those who do it.
Wife tried it several years ago, unfortunately didn’t work for her.
Look like someone pinched when they should have pushed.
Are there any areas of the world with sub populations that have very little or near zero Parkinsons present and if yes, does what they eat create that lack of disease presence?
Interesting!
Capitalist here thinking about monetizing my #2…. Better yet, outsourcing it to India and having a factory style production line…. Or, smaller volume higher quality? No, I’ll create a brand that offers #2 from celebrities and pro athletes offering a royalty on sales to inspire the ‘producer’ to self promote their uh.. product. “When it comes time for #2, choose the best for you.” will be the tagline. Then I’ll license the product, franchise the operation, do an IPO, AND BECOME THE KING OF CRAP!
I better just go mow the lawn.
Fecal transplants are also sometimes used in the treatment of C. diff (Clostridioides difficile).
Don’t try this at home.
Fecal transplant appears to confer many health conditions from the donor.
A good approach is to identify a location known for healthy people, select an especially healthy young person there, and purchase their poop.
Nope, you need Tom Bradys poop! people kill for tom bradys poop, its super poop!!
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