Metabolization is a factor. My now passed friend had pretty good information and advice having been a federal doctor.
His methods for using percocet and oxy was that 90% of medicine is metabolized in the stomach. Thus, a person can break off a small piece and hold it under their tongue and get about 4 doses from one.
Sometimes you skip a week and your body resets. That’s probably the positive with the disruption of supply these days.
It is routine to hurt and as I have learned to mitigate pain my best days are those going to the spa and hitting the steam, sanu , hot tub and then actually swimming for 30 - 60 minutes.
Since I am not a clinical pharmacologist I can’t dispute what you are saying .. The problem isnt the stomach for me it is the liver enzymes.
This article lays out the mechanics of OXY
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704133/
So for me, I have no CYP2d6 and some variants in CYP3a4 that are in the ‘emerging’ category of clinical study. But what is interesting is that your post made me look up that article and in that article it talks about uridine diphosphate glucuronosyltransferase (UGT) for metabolism. There are several genes related to that so I pulled up my Nebula DNA.
Sure enough, I have a red flag in one of them that when you look it up it mentions tramadol. So this requires me to do more research into the rest of the genes and variants related to UGT and pain relievers
But I will give the under the tongue thing a try just to see what happens.