Posted on 01/07/2024 1:23:13 PM PST by nickcarraway
The drug hydroxychloroquine was prescribed off-label during the pandemic and touted in particular by a prominent French researcher.
The antimalarial drug hydroxychloroquine may have induced nearly 17,000 deaths in six countries during the first wave of the COVID-19 pandemic.
This molecule was presented during the pandemic as a miracle cure by a minority of health professionals, among them the French microbiologist Didier Raoult.
The scientist’s belief that the drug was a cure for COVID-19 was soon echoed by some policymakers. French President Emmanuel Macron notably visited his facility and US President Donald Trump recommended the drug in 2020, stating that he had already taken it.
Avoiding COVID was about more than just keeping 2 metres apart, study finds The use of the drug sparked controversy as many health specialists noted the lack of research or scientific evidence of its effectiveness against COVID-19.
The US Food and Drug Administration (FDA) issued an emergency use authorisation of hydroxychloroquine (HCQ) in March 2020 but revoked it in June.
The drug was found in particular to cause severe side effects such as heart rhythm abnormalities.
Nearly 17,000 deaths induced by hydroxychloroquine A new study published in Biomedicine & Pharmacotherapy now estimates the fallout from the drug’s off-label use.
Researchers led by Jean-Christophe Lega, a Professor of Therapeutics in the Lyon, France hospital system, investigated studies conducted in France, the United States, Belgium, Italy, Spain, and Turkey from March 2020 until July 2020.
"HCQ use was associated with an 11 per cent increase in the mortality rate in a meta-analysis of randomised trials," the study noted, citing a meta-analysis published in 2021 in Nature which the researchers used to calculate the number of deaths induced by the drug.
'It’s not gone. It’s changing. It’s killing': The COVID variants the WHO is watching closely The estimated number of deaths in European countries was roughly 240 in Belgium, 199 in France, 1,822 in Italy, and 1,895 in Spain.
"What we need to bear in mind is that this is a rough estimate, in the sense that it only concerns a few countries over a short period, and that the total number of deaths is probably much higher," Lega told French broadcaster France 3.
The results should be taken with caution as it is a statistical analysis. One limitation of the study was that in France, Turkey, and Belgium, in particular, data concerning exposure to the drug was scarce.
Yet the researchers say: "This result argues in favour of tightly regulating access to off-label prescriptions during future pandemics".
If you are taking a drug that is metabolized by one or more P450 enzymes to be effective AND you are taking a weak inhibitor AND you already have genetic problems...then YES...you should be aware of the issue..because a weak inhibitor now has the potential to have a strong effect.
This is one of the points that study on HCQ was making about patients in the hospital with COVID. I think they mentioned QUercetin in that study but it has been awhile since I read it.
And btw, the Flockhart table is pretty stringent on when they will change the drugs on that list. So when Covid first started HCQ wasn’t even listed but now it is listed as a weak inhibitor. In reality..it is a substrate...but they need more studies before they will change it.
The drug hasn’t changed during those years. Doctors were clueless..and likely still are about HCQ and P450. It will take more studies before Flockhart table will change and meanwhile patients like me have to figure out how to navigate Drugs that could be clearly problematic.
I have one Doctor that said don’t take it for my auto immune issues. Safer not to take it. I agree. Of course, I haven’t had Covid.
Which is criminal knowing it was pulled from use for Ebola when they discovered its mortality rate and the kidney and liver destruction for a great number of those who survived it.
Academia is academic fraud.
Psychology Today shares that “when caught in the act with their unscrupulous behavior, most sociopaths and psychopaths will not show signs of contrition or remorse (unless it is strategically advantageous for them to do so). On the contrary, they are more likely to double or triple down on their aggressive tendencies, increase hostility, deny responsibility, accuse and blame others, and maintain a facade of arrogance and conceit.”
Sounds just like the FDA and CDC.
week 71 wrote: “Pretty juvenile response. The inertia of your vaccine religion is heading down the wrong direction and you know it.”
The ‘juvenile responses’ come from the anti-vaxxer cult. That cult has been heading in the wrong direction for many months and you know it. The vaccines have saved millions but the cult won’t admit it.
Is EuroNews comparable to AP? Is it as trustworthy?
HQ is why Africa had only a minimal experience with WuFlu.
HCQ for COVID-19: real-time meta analysis of 417 studies
https://c19hcq.org/meta.html
What evidence outside the lies do you have that shows that the vaccines saved any lives?
I don’t believe that you can take a vaccine that was untested before it was released, and Fauci that vaccines need about ten years worth testing to be worth anything, and legislate it so you choose between eating and not taking the vaccine and consider it safe.
We were the guinea pigs for an unproven vaccine, so they could collect data on the effects. Billions of people served as data points as to the effectiveness of the vaccine, with no proof that it worked. Millions of people died from this vaccine.
They lied about covid origins.
They lied about the need to take the vaccine.
They profited by $100 billion dollars, with Fauci earning about $30 million.
They lied about the vaccine being safe.
Do you really think they will tell the truth about how many people died from taking the vaccine?
Do you think all the post vaccinated youth dying of blood clots is just a coincidence?
Use of HCQ is only one of the reasons that Africa had far less problems with COVID-19 than most of the world. Two other major reasons are an extremely young population and little obesity.
The study's author(s) claim no funding was received. They are getting smarter - they usually list the pharmas.
They get around to admitting how much they guessed, assumed, estimated etc. For example they're somewhat puzzled as to how accurte their data is because they didn't have good data on comorbidities. Recall people were being coded as having died from Covid when they actually died from cancer - so add in those people who had died of cancer and had taken HCQ. This study means nothing. But, it will be regarded as authoritative....
https://www.sciencedirect.com/science/article/pii/S075333222301853X#sec0075
"Our study has some limitations. First, some of the results should be taken with caution, particularly the results obtained in France, Turkey and Belgium. For these countries, data concerning HCQ exposure were scarce. As a result, estimates in these countries are more imprecise. Unfortunately, due to the lack of political determination to assess the effect of off-label prescriptions during the COVID-19 crisis, it is unlikely that additional large-scale data will be generated from these countries. Second, the data used were extracted directly from cohort studies. However, a practice study carried out in France showed that HCQ prescription was highly heterogeneous and largely influenced by several factors, the most important being the presence of an established departmental procedure supporting its prescription [95]. Taken together, these results suggest a strong centre effect based, which may have biased the true HCQ exposure. Unfortunately, hospital databases were not available to precisely determine the true HCQ exposure in deceased patients with COVID-19. Third, we estimated the mortality of hospitalised patients using data from published cohorts. Similarly, mortality rates significantly varied across hospitals and regions, which may have been influenced by variable age, sex, comorbidities, ICU capacity, improvement in COVID-19 management, and trust of the population in the national health system and pandemic-related policies [96], [97], [98]. This is supported by our sensitivity analysis using national surveillance data from Spain and USA. However, the relative effect of HCQ exposure on outcomes was not modified. Fourth, we did not use all sources of uncertainties related to variables included in the models. We only included variables related to the HCQ treatment effect. Thus, HCQ-related deaths may be considerably over- or under-estimated. Indeed, the 95% confidence interval of the OR of all-cause mortality related to HCQ ranged from 2% to 20%. In other words, our results might be overestimated by a factor 5 (i.e. the actual number of deaths related to HCQ would be ≈3000 deaths) or underestimated by a factor 2 (i.e. the actual number of deaths related to HCQ would be ≈30000 deaths). Thus, the effect of HCQ on mortality was the main source of uncertainty for the proposed estimates. Finally, some estimates could not be calculated due to missing or incomplete information, such as the number of hospitalisations in China, South Korea, Russia and Qatar. The number of deaths related to HCQ worldwide was obviously underestimated because of the lack of studies in regions, such as East Europe, United Kingdom, Germany, Scandinavia, Africa, and South America. Since the number of inhabitants living in the countries included in the present study was ≈ 600 million, we might speculate that the real number of HCQ-induced deaths might be significantly higher given the wide use of HCQ during the first and subsequent waves in numerous countries [85], [99], [100]. In addition, the number of deceased outpatients exposed to HCQ is unknown. Accordingly, the present results should be viewed as rough estimates only.
In conclusion, the number of HCQ-related deaths is estimated at 16990, even though this number is probably underestimated because of the lack of data from most countries. More importantly, this study illustrates the limitations of treatment-effect extrapolation from chronic to severe conditions without accurate data and the need to produce quickly high-level evidence from RCTs in case of emergent diseases."
They are just reporting on what the study found.
Meanwhile, Ecuador used HCQ to wipe Covid off the map because they couldn’t afford the more expensive clot shot.
The antimalarial drug hydroxychloroquine, used in combination with zinc and azithromycin, was highly effective.
One of our adult sons in his mid 50’sf in the second spring of Covid got whacked fairly hard with the Delta version.
A friend of this son, working in medical care, of got the above medicines to us, and we got them to another relative, who got the meds to our son.
Within 2-3 days, our son was feeling better and took these drugs with zinc for a total of 10 days.
What was interesting was his wife, an adult son and adult daughter (an Rn), were in the same home and never caught nor had this B$.
There’s also the routine use of Ivermectin to prevent African River Blindness.
Africa and Ivermectin
https://archive.is/2021.08.28-042601/https://threadreaderapp.com/thread/1431339779703017477.html
The infographic there is excellent. Summary: The parts of Africa where Ivermectin is in widespread use to prevent a terrible parasitic disease, African River Blindness, also have very low Covid incidence.
HCQ was approved by the FDA decades ago and has been used safely for decades. The mRNA vaccines only received emergency use approval. Mired in politics and most likely bribery, it may be decades before a truthful consensus is reached - and then no one will care.
Here’s a parallel case. Democrats used to call Joseph Stalin “Uncle Joe.” They loved the man. There were reports of intentional starvation in the Ukraine, but the New York Times denied the reports and most of the press remained silent. It’s now known that millions of Ukrainians were murdered through starvation. It’s not a pretty way to go. There was cannibalism.
I took HCQ for about ten days on two occasions. It’s my go to drug when I catch something.
Total BS based simply on the history of HCQ side effects from the many years of its existence. Follow the money for the reason for this studies conclusions.
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