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Very high levels of 'good cholesterol' may be associated with dementia risk, study shows (HDL > 80 mg/dL = 27 - 42% increased risk)
Medical Xpress / Monash University / The Lancet Regional Health—Western Pacific ^ | Nov. 30, 2023 | Dr. Monira Hussain et al

Posted on 12/04/2023 9:29:27 AM PST by ConservativeMind

Abnormally high levels of HDL-C, colloquially known as "good cholesterol," are associated with an increased risk of dementia in older adults, a study has found.

Researchers said very high levels of HDL-C linked to dementia risk in this study were uncommon and not diet related, but more likely to reflect a metabolic disorder.

The findings may help doctors to recognize a group of older patients potentially at risk of dementia.

Over an average 6.3 years, participants with very high HDL-C (>80 mg/dL or >2.07 mmol/L) at study entry were observed to have a 27% higher risk of dementia compared to participants with optimal HDL-C levels, while those aged 75 years and older also showed a 42% increased risk compared to those with optimal levels.

Very high HDL-C levels were categorized as 80 mg/dL (>2.07 mmol/L) or above. The optimal level of HDL-C of 40 to 60 mg/dL (1.03–1.55 mmol/L) for men and 50 to 60 mg/dL (1.55–2.07 mmol/L) for women was generally beneficial for heart health.

Among 18,668 participants included in this analysis, 2,709 had very high HDL-C at study entry, with 38 incidents of dementia in those aged less than 75 years with very high levels, and 101 in those aged 75 and more with very high levels.

First author Dr. Monira Hussain said that further research was needed to explain why a very high HDL cholesterol level appeared to affect the risk of dementia.

Dr. Hussain said, "While we know HDL cholesterol is important for cardiovascular health, this study suggests that we need further research to understand the role of very high HDL cholesterol in the context of brain health."

"It may be beneficial to consider very high HDL cholesterol levels in prediction algorithms for dementia risk."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cholesterol; dementia; hdlc; hdlcholesterol; wereallgonnadiesoon
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To: Seruzawa

“No matter what you do, you are wrong.”

BINGO


21 posted on 12/04/2023 11:04:43 AM PST by Magic Fingers (Political correctness mutates in order to remain virulent.)
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To: muir_redwoods

My 3 main food groups are Hot Wings, Pizza, and Enchiladas. I should live forever. But I won’t...


22 posted on 12/04/2023 11:07:41 AM PST by donozark (Even when Paul Pelosi isn't drinking, he's getting hammered.)
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To: BigFreakinToad

I think some is hereditary, but my doctor said Krill oil and Omega-3 will raise it. I take both. Exercise will raise it the most. A good HDL level protects your heart from the bad LDL if your LDL is high. I only weigh 135lbs but I’m fairly fit. I eat good food, not fast food.

Still:

I had mine checked 6 months ago and my total cholesterol was 305. My LDL was 214. My triglycerides were 179. My VLDL was 250. My HDL was 55. She almost freaked and started me on Nexletol. I also started a more potent Krill supplement. Nexletol is not a statin. I have been allergic to statins.

After 6 months, my total cholesterol is down to 214, my triglycerides are 86, and my VLDL is down to 17. My HDL is 66. My LDL is 134.

I had my arteries scanned and there was NO plaque buildup at all and that’s a miracle since I have the genetically high LDL and have for over 30 years. My PAD test was normal, and I didn’t have A-fib (just turned 69). The only thing that can make that even possible is the high HDL and genetics. I should have had three bypasses by now!


23 posted on 12/04/2023 11:10:40 AM PST by Melinda in TN
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To: Melinda in TN

I’m in terrible shape and take cholesterol meds. But I’ve cut way way back on beef and somehow my good, which has historically low, crawled into the normal range.
I wish I could exercise, but when you have bone on bone in your knees, walking isn’t fun.
I’d give just about anything to weigh 150 or 165, but I stand a better chance of flapping my arms and flying to the moon.


24 posted on 12/04/2023 11:20:36 AM PST by BigFreakinToad (Remember the Biden Kitchen Fire of 2004)
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To: BigFreakinToad

I have one bad ankle from being knocked down by a dog five years ago, but it’s not bone on bone. It was misdiagnosed and not treated promptly. A little arthritis and short tendons but when it acts up, I wear a brace. That happens mostly in winter.

Knees are good.

I rarely eat red meat but do eat a lot of fish and chicken. I eat an avocado every day with a splash of olive oil, malt vinegar, and balsamic vinegar instead of store-bought dressing. I cook a pot of white beans on the stove twice a week with onion and garlic. I eat a cup each day. I eat a tablespoon of raw honey a day. Eat nothing out of a can or a box. No added sugar to anything. Until I messed up the ankle, I was riding a mountain bike 30 miles through the woods three times a week and walking 3-5 miles the other days, at 64-years-old. Since I had to stop most of that, I gained a little bit of weight, but my BMI is still normal.

The ankle improves each year, so I hope to be back on a bike soon.

Sit down and figure out what you CAN do and do it. Anything is better than nothing. Even if you sit in a chair and lift weights, that’s good. I hope you can do what you need to do to get better!

I have a picture of me on my profile that was taken at 64 about two weeks before I messed up the ankle. Not the first pic. That’s me at 17, LOL The second picture is me at 64.


25 posted on 12/04/2023 11:36:05 AM PST by Melinda in TN
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To: Melinda in TN

Man, you are my hero. I’m 63 and a pile of junk, which of course is all my fault.


26 posted on 12/04/2023 11:52:31 AM PST by BigFreakinToad (Remember the Biden Kitchen Fire of 2004)
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To: BigFreakinToad

You are six years younger than me. I’ll tell you what I tell my husband. He’s 85 and sits all day in a recliner. He had blood clots a year ago that went to one lung and put him in the hospital for a week, from sitting.

Start moving something. LOL It doesn’t matter what, just move. As long as you are still above ground, it’s not too late. 😉 Search exercises online for people with bad knees. You need to move your legs even if you aren’t putting a lot of weight on them. The doctors said his blood clots came from his legs and inactivity. Do knee friendly activities. You don’t have to run or walk marathons.

I saw a woman in a wheelchair the last time I walked our local paved trail. She was paralyzed from the waist down. She had arms the size of a male body builder and boy could she fly in that wheelchair. She had somebody with her to get the wheelchair in and out of the vehicle but once on the trail, she was flying! Her legs didn’t work but there was nothing wrong with her arms.


27 posted on 12/04/2023 12:17:25 PM PST by Melinda in TN
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To: ConservativeMind
First author Dr. Monira Hussain said that further research was needed

$$$

28 posted on 12/04/2023 12:43:39 PM PST by T Ruth (Mohammedanism shall be destroyed.)
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To: Melinda in TN

yep, I know. I need to move despite the pain. I sit way way to much


29 posted on 12/04/2023 12:56:27 PM PST by BigFreakinToad (Remember the Biden Kitchen Fire of 2004)
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To: BigFreakinToad

My husband has two bad ankles. That’s one reason he sits too much. I understand the pain and don’t do anything that makes your knees worse. I got him some hand weights and now he lifts weights from his recliner. He also marches his feet while sitting and does squats while standing at the kitchen sink. I’m quite the little drill sergeant. Lol


30 posted on 12/04/2023 1:32:29 PM PST by Melinda in TN
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