Posted on 10/18/2023 9:34:37 PM PDT by ConservativeMind
A new study has identified a compelling link between vitamin B12 deficiency and chronic inflammation, which is associated with a range of health problems including cardiovascular disease, diabetes, and neurodegenerative disorders.
The research examined the effects of circulating B12 concentration on the levels of two key inflammatory markers in both humans and mice.
Vitamin B12, an essential nutrient with roles in various physiological processes, is known to be critical for overall health. Its deficiency can be the result of dietary insufficiency or inefficient absorption in the body. This can lead to a range of complications, including neurological disorders. While previous research has hinted at the potential anti-inflammatory properties of vitamin B12, the precise relationship is not fully understood.
Now, researchers have investigated the effects of vitamin B12 on the levels of two molecules in the body which promote inflammation, specifically interleukin (IL)-6 and C-reactive protein (CRP).
Rosa M. Lamuela-Raventós explained the motivations behind the study.
"Establishing the relationship between inflammatory markers like IL-6 and CRP [and vitamin B12 levels] could have direct clinical relevance and open doors to novel therapeutic strategies."
The study utilized samples from a randomized subsection of participants in PREDIMED, a large clinical trial, designed to assess the effect of the Mediterranean diet on the primary prevention of cardiovascular disease. An assessment of the serum levels of vitamin B12 and the concentrations of the inflammatory markers revealed a correlation between the two.
"Our study found that in general, the more vitamin B12 an individual has, the lower their inflammatory markers are—we call this an inverse relationship," explained Marta Kovatcheva.
The study also observed the same relationship between vitamin B12 and inflammatory markers in naturally aged mice, offering a valuable avenue of using mouse models to delve deeper into the underlying mechanisms of the inverse correlation.
(Excerpt) Read more at medicalxpress.com ...
Well, ouch! I associate my shin with the bone and skin on top of that bone of my legs below my knees. How in the world do you get a needle in there? Don’t tell me. That was a rhetorical question.
it’s the muscle to the right of the bone on right leg (or opposite on the left). It didn’t hurt at all. You can feel the muscle and if you move alittle to the right there’s a dip before the next muscle and the recommendation is to inject in the dip :)
Thanks. Any discomfort in the hours/days following the injection such as nausea or headaches?
Appreciated. I was curious about the injection site. Thanks.
Amazon also has B-12 patches you can stick on for time release action thru the day.
Gene, the B12 shots have never given me any side effects other than they hype me up big time, like 40 cups of coffee hyped up. Get lots of stuff done in the first 36 hours. 😆 Then it wears off. I’m told the type of B12 shot makes a difference but I don’t know the difference between shots.
this looks like a good site and form to buy. Methyl B12 is the best form
https://perniciousanemia.org/b12/injections/buy/
they sell it powdered in a vial then you buy saline and syringes.
are you calling us drunks and bikers??
:)
Oh no I’d never do that, besides, there is nothing wrong with being either a drunk or a biker. 😆 It’s just something I noticed at my health food store shot clinic. The bikers were self evident, the drunks was just me guessing by look. 👀
haha! I’d call ‘em smart though if they’re looking at upping their B12
Cool re patches. Did you happen to notice if your BP was elevated?
I haven’t tried the patches, I saw them when I ordered my BComplex vitamins. My BP runs slightly high anyway so I’m on a low dose BP med.
thanks
I have never had any discomfort following the injection. Before I learned to self-inject, a nurse once gave me the shot. When she called the next day to ask how I was doing, I had totally forgotten about the shot!
I began my B12 regime back around 2010, maybe a year earlier or later. At this time I lived in the jungle of Papua, Indonesia. Medical care was unreliable. I was having some vague symptoms of fatigue, stomach issues, a fuzzy-creepy headache which started in the back of my neck and went upwards into my head. It wasn’t like other headaches, but really felt like a fungus growing between my skin and my skull. I realize that is a strange description, but I haven’t yet come up with a better one.
A nurse/friend thought I might have developed pernicious anemia and recommended I try B12 injections. I started receiving 3mL twice a day. In about 2 or 3 days the headache had almost completely disappeared. The headache would begin to reappear about 8 hours later. I would get another shot and short time later the headache disappeared again. After a while it completely disappeared.
I did have more energy after the shots. The abdominal symptoms disappeared. I still continue with the B12 shots at a rate of 3mL per week.
It turns out I do not have pernicious anemia. I have an autoimmune hemolytic anemia called cold agglutinin disease (CAD). While not a front-line treatment, the B12 helps and is now prescribed by my hemotologist.
HTH
FWIW, I am a biker (Suzuki Shogun 110). But you can’t tell by looking at me. People who look at me see a slightly doty, frumpy, grandmother-type of old woman.
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