Posted on 10/18/2023 9:34:37 PM PDT by ConservativeMind
A new study has identified a compelling link between vitamin B12 deficiency and chronic inflammation, which is associated with a range of health problems including cardiovascular disease, diabetes, and neurodegenerative disorders.
The research examined the effects of circulating B12 concentration on the levels of two key inflammatory markers in both humans and mice.
Vitamin B12, an essential nutrient with roles in various physiological processes, is known to be critical for overall health. Its deficiency can be the result of dietary insufficiency or inefficient absorption in the body. This can lead to a range of complications, including neurological disorders. While previous research has hinted at the potential anti-inflammatory properties of vitamin B12, the precise relationship is not fully understood.
Now, researchers have investigated the effects of vitamin B12 on the levels of two molecules in the body which promote inflammation, specifically interleukin (IL)-6 and C-reactive protein (CRP).
Rosa M. Lamuela-Raventós explained the motivations behind the study.
"Establishing the relationship between inflammatory markers like IL-6 and CRP [and vitamin B12 levels] could have direct clinical relevance and open doors to novel therapeutic strategies."
The study utilized samples from a randomized subsection of participants in PREDIMED, a large clinical trial, designed to assess the effect of the Mediterranean diet on the primary prevention of cardiovascular disease. An assessment of the serum levels of vitamin B12 and the concentrations of the inflammatory markers revealed a correlation between the two.
"Our study found that in general, the more vitamin B12 an individual has, the lower their inflammatory markers are—we call this an inverse relationship," explained Marta Kovatcheva.
The study also observed the same relationship between vitamin B12 and inflammatory markers in naturally aged mice, offering a valuable avenue of using mouse models to delve deeper into the underlying mechanisms of the inverse correlation.
(Excerpt) Read more at medicalxpress.com ...
You can check the status of vitamin B12 and C-reactive protein in blood tests, with CRP being the more common test. If you believe your inflammation is already low, ask your doctor for an hs-CRP test, which can accurately interpret just how low your levels get, as the normal CRP tests assumes you have more than a little, and can’t read low values, well.
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Bkmk
I try to eat low carb so I have eggs almost every day.
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Good info, I need to up my B12 intake. I have an inflammatory disease and I can’t stress enough that everyone say 55+, at there annual physical ask to have their hs-CRP levels checked when they do all the other normal blood test. Inflammation is a hidden very bad health issue that no one knows you have if not for the hs-CRP test. High Sensitivity -c Reactive Protein test. My GP didn’t look at mine when my issue arose, the neurologist did mine and my cRP was 156, it is supposed to be under 10 at most labs. I could have gone blind if he didn’t check and that test led to a biopsy of my temple artery which confirmed my diagnosis of Giant Cell Arteritis.
Take your fish oil kids!
Thank you. We were giving the cat B12 shots because it’s believed related to her inflammatory bowel syndrome, low levels being both a cause (perhaps) and a result of her suggestive system being unable to absorb enough B12.
As her condition improved, we were able to shift to oral B12 because she can absorb it now.
So interesting to see this study discussing B12, absorption
and inflammation.
The ebb & flow of B12 is known to be a slow and lengthy process. Any discomfort with the shots?
Gingivitis (gum inflammation) is directly linked to heart disease. Inflammation is bad for the human body. Take B12 and brush your teeth freepers!
Your last sentence mentions you had a biopsy of your temple artery done.
How does a doctor or nurse practitioner take a biopsy of an artery? Is medicine now so precise that a fragment of a very sensitive, still pulsating membrane like an artery can safely be done? If so, I am impressed.
B-12 is the only supplement I take, its water soluble so any excess is simply eliminated, your body takes what it needs and dumps the rest. It really does give u a boost.
Yes. They sting a bit. I have found that if I push down on my skin as I'm receiving my shot (which I administer) and I inject very slowly, the sting can be mitigated.
There is nothing better than a B12 cattle injection. You can get on Amazon. Your muscles and stress just drop away.
You can get injectable B12 used for cattle. Syringes at Walmart or Amazon. Get the 1/2 inch.
I occasionally inject right below neck or into shoulder between the blades.
I have had acute hypertension and this will limber you up within seconds and your entire neck/ shoulder area just go limp and relaxed .
You cannot overdose so no worries there.
It only hurts if you reuse the needles.
Calm down, everyone.
Two tablespoons of cricket flour give you 270% of your daily value of B12:
https://www.cricketflours.com/cricket-nutritional-value/
The biopsy was done on my temporal artery just above, and to the left of my left eye on my forehead. I was put under, the doc made a 2 inch incision on my forehead near the left hairline, and ties off both ends of the artery and takes about a 4 or 5mm section of the artery out. I was told the artery would re-route and re-grow itself after being tied off. It took about 15 minutes and then a week of recovery which was just sleeping with head elevated, no bending over or heavy lifting for a week, plus anti biotic ointment on the incision and stitches.
The biopsy was done, believe it or not at Cincinnati Eye Institute, it was done by the plastic surgeon there who usually does eye lifts, and tear duct surgery. After the biopsy my artery was looked at under the microscope and my cells in the artery were Giant. Hence my diagnosis of Giant Cell Arteritis. An inflammatory auto immune disease. I had 3 months of continuous headaches and saw different docs and had MRIs and Cat Scans with no obvious tumors or issues found. Only when the neurologist checked my hs-cRP blood test did we find the inflammation was very high, this led the neuro to send me for the biopsy which is the Gold Standard for diagnosis of GCA. Unfortunately I was positive with biopsy.
I should note the Surgeon did a wonderful job and most people don’t even see my scar on my forehead until I point it out to them. I have also had 6 months of numbness on the left side top of my head while the nerves regrow after the surgery incision. It gets better every week and I only notice it numb now when I brush my hair.
The biopsy was done on my temporal artery just above, and to the left of my left eye on my forehead. I was put under, the doc made a 2 inch incision on my forehead near the left hairline, and ties off both ends of the artery and takes about a 4 or 5mm section of the artery out. I was told the artery would re-route and re-grow itself after being tied off. It took about 15 minutes and then a week of recovery which was just sleeping with head elevated, no bending over or heavy lifting for a week, plus anti biotic ointment on the incision and stitches.
The biopsy was done, believe it or not at Cincinnati Eye Institute, it was done by the plastic surgeon there who usually does eye lifts, and tear duct surgery. After the biopsy my artery was looked at under the microscope and my cells in the artery were Giant. Hence my diagnosis of Giant Cell Arteritis. An inflammatory auto immune disease. I had 3 months of continuous headaches and saw different docs and had MRIs and Cat Scans with no obvious tumors or issues found. Only when the neurologist checked my hs-cRP blood test did we find the inflammation was very high, this led the neuro to send me for the biopsy which is the Gold Standard for diagnosis of GCA. Unfortunately I was positive with biopsy.
I should note the Surgeon did a wonderful job and most people don’t even see my scar on my forehead until I point it out to them. I have also had 6 months of mild numbness on the left side top of my head while the nerves regrow after the surgery incision. It gets better every week and I only notice it numb now when I brush my hair.
What dosage do you take?
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