Study findings could pave the way for development of new strategies to prevent and treat obesity (Inulin fiber helps)

Medical Xpress / University of Nottingham / Cell Reports Medicine ^ | April 5, 2023 | Cristina Menni et al

[ConservativeMind]

New research has shown that weight loss, or bariatric, surgery can significantly alter the levels of bile acid associated with higher appetite, as can taking fiber supplements but to a lesser degree.

Bile acids are a marker of poor cardiometabolic health that can affect liver function and inflammation.

A study has shed light on the molecules underlying the benefits of this kind of surgery on patient appetite and metabolism.

Researchers studied a group of patients in Amsterdam who had undergone bariatric surgery by measuring levels of bile acids before surgery and a year post-operation. They also studied bile acids from two population studies.

The study found that a specific bile acid called isoursodeoxycholate (isoUDCA), which is associated with higher appetite and worse metabolic levels, decreased after bariatric surgery and after taking fiber supplements. Levels of isoUDCA did not decrease after consuming omega-3 supplements.

Professor Ana Valdes said, "Bariatric surgery also improves their liver function and their metabolism."

Bariatric surgery is also only suitable for those who are severely obese, and understanding whether isoUDCA can be modified by lifestyle interventions could lead to more targeted treatments for obesity.

Another key finding was seeing the strong influence of gut microbes on the levels of isoUDCA. This confirms that the gut microbiome is key to determining the outcomes of bariatric surgery and sheds light on the ways in which gut microbes modify a person's metabolism.

Professor Tim Spector said, "This study highlights the key role that fiber plays in appetite regulation and metabolism, harnessed by specific gut microbes. Advanced gut microbiome testing (as used by ZOE) provide personalized insights that can support metabolic health. The gut microbiome and its chemical products such as these bile acids hold huge promise for reducing obesity without the need for invasive surgery."

[ConservativeMind]

The paper specifically states inulin, in a 20 gram amount, provided the beneficial fiber option, alluded to in the above article.

That amount of inulin will cause gas effects (>5 grams does). A prior study I posted showed benefits from inulin up to 20 grams, then beyond that, issues could arise, so consider not going beyond that amount.

Additionally, another study I posted showed that anyone with liver cirrhosis can have Portosystemic shunts, with which, somehow, caused inulin to encourage liver cancer in mice, as a result.

Some things in life have double-edged swords, involved.

[ConservativeMind]

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[bigbob]

Here’s a strategy: Eat half.

[stevio]

LOL. Nah, let’s let science do it for us.

[Pollard]

Eat real food and don’t be a gluten. Get off the couch/out of the chair.

[Disambiguator]

Don’t be a gluten.

🤣

[redangus]

And for some of us Inulin causes not only gas, but diarrhea. Which I suppose would help with weight loss.

[dominusobiscum]

So easy, yet so difficult!

[Pollard]

Ha, I had to talk to my autistic son last night about his rice as a comfort food thing. He’s a rice glutton. He would have downed a large, $10.00 fried rice in a sitting.

We never did try the gluten free diet that possibly helps with autism because there would be almost nothing he’d eat if we did. Rice is gluten free but he likes his cereal.

[Disambiguator]

You should check out the GAPS diet. It was developed by a neurologist to help her autistic son. It’s not easy, but it works.

https://www.gapsdiet.com/