Posted on 02/08/2023 8:59:38 PM PST by SeekAndFind
Young blood plasma transfusions for anti-aging are popular with some wealthy elites. There are claims that young blood rejuvenates the body's organs. But turning back the body's clock with transfusions might not need to be done anymore following research from Columbia University in New York that states an anti-inflammatory drug can rejuvenate the body and possibly increase the human lifespan by decades.
"An aging blood system, because it's a vector for a lot of proteins, cytokines, and cells, has a lot of bad consequences for the organism," Emmanuelle Passegué, Ph.D., director of the Columbia Stem Cell Initiative, who's been studying how blood changes with age, said in a statement.
"A 70-year-old with a 40-year-old blood system could have a longer healthspan, if not a longer lifespan," Passegué said.
Instead of a liter of plasma from younger donors that might cost thousands of dollars, researchers found young blood could be produced in pill form.
That pill is an anti-inflammatory drug called anakinra , already approved for use in rheumatoid arthritis. Passegué and graduate student Carl Mitchell discovered anakinra reverses some of the effects of age on the hematopoietic system of mice.
"These results indicate that such strategies hold promise for maintaining healthier blood production in the elderly," Mitchell said.
What didn't work, and explained by Passegué and her team in a 2021 study in the Journal of Experimental Medicine, was:
to rejuvenate old hematopoietic stem cells, in mice, with exercise or calorie-restricting diet, both generally thought to slow the aging process. Neither worked. Transplanting old stem cells into young bone marrow also failed. Even young blood had no effect on rejuvenating old blood stem cells.
Her team then discovered the benefits of anakinra in mice:
Mitchell and Passegué then took a closer look at the stem cells' environment, the bone marrow. "Blood stem cells live in a niche; we thought what happens in this specialized local environment could be a big part of the problem," Mitchell says
With techniques developed in the Passegué lab that enable detailed investigation of the bone marrow milieu, the researchers found that the aging niche is deteriorating and overwhelmed with inflammation, leading to dysfunction in the blood stem cells.
One inflammatory signal released from the damaged bone marrow niche, IL-1B, was critical in driving these aging features, and blocking it with the drug, anakinra, remarkably returned the blood stem cells to a younger, healthier state.
Even more youthful effects on both the niche and the blood system occurred when IL-1B was prevented from exerting its inflammatory effects throughout the animal's life.
The researchers are now trying to learn if the same processes are active in humans and if rejuvenating the stem cell niche earlier in life, in middle age, would be a more effective strategy.
Meanwhile, "treating elderly patients with anti-inflammatory drugs blocking IL-1B function should help with maintaining healthier blood production," Passegué says, and she hopes the finding will lead to clinical testing.
"We know that bone tissue begins to degrade when people are in their 50s. What happens in middle age? Why does the niche fail first?" Passegué says. "Only by having a deep molecular understanding will it be possible to identify approaches that can truly delay aging."
Of course, the research is still very early, and results have yet to be tested on humans. But that might not stop people from Googling the drug as a possible anti-aging solution.
Stories like this are out there and unfortunately believable:
https://www.bitchute.com/video/AI8BhN2V3fhd/
A partial listen is likely sufficient…
Snake oiil in pill form.
You may be onto something. A recent medical review article notes that MSM has suppressive effects on IL-1β, which is the molecule that promotes aging that the drug studied, Anakinra, suppressed.
thanks~~~~
Turmeric and black sead oil together, read about it.
Still looking for Ponce de Leone’s fountain
If you want Kineret, you better bring your wallet.
It could be. Liposomal delivery in a pill is already here and it has absorbability and bioavailability comparable to IV modality.
Where does it say anything about children? Younger is 40 according to this article.
Only if they are not collecting Social Security .....
Otherwise known as adrenochrome?
In China for centuries, they collect the urine of teens. They do this by having urinals even for girls, with a stool for stools. They set these up in school settings, and collect it, then harvest the hormones. It is the basic way you get bio-identical hormone treatments including testosterone, estrogen and HGH among others. It is what keeps Suzanne Sommers looking younger, and her husband “firm and ready” like rabbit. HGH speeds healing, and stimulates muscle growth as well as that feeling of youth, like you will live forever.
ping
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.