Discovery of Er Blood Group System

University of Bristol ^ | 24 September 2022 | School of Biochemistry

[SunkenCiv]

Scientists from the University of Bristol and NHS Blood & Transplant (NHSBT) have discovered a rare new blood group system. The findings, published in Blood, the journal of the American Society of Hematology, also solve a 30-year mystery...

In this study, individuals with alloantibodies against a collection of antigens termed Er, that were first observed more than 30-years ago, were investigated by applying a powerful technique allowing simultaneous analysis of all their gene coding DNA sequences. Specific changes were identified in the gene coding for the Piezo1 protein, which would result in the production of an altered protein on the cell surface of these individuals. Using gene editing in an immortalised cell-line developed in Bristol, the Piezo1 protein was first removed and then reintroduced to definitively prove that alloantibodies to Er antigens (including two never before reported) bind to Piezo1, and that Piezo1 is required for Er antigen expression.

Using a combination of cutting-edge DNA sequencing and gene-editing techniques, the team were able to conclusively show that Piezo1, a protein of widespread biological interest, is the carrier for these sites (and more) and, in so doing, establish Er as a new blood group system.

[SunkenCiv]

Bloodtype/bloodtypes keywords, sorted, duplicates out:

• Your blood type could predict your risk of having a stroke before age 60, new study suggests [09/01/2022]
• Molecular archaeology: What ancient genes tell us about who we are [06/06/2022]
• Blood type may offer insights into risk of blood clot in people with cancer (All non-O blood types have venous thromboembolism risk at three months after any cancer diagnosis) [04/13/2022]
• What Is the Golden Blood Type? [09/11/2021]
• Neandertal and Denisovan blood groups deciphered [08/08/2021]
• Blood type not a Covid-19 risk factor in US; inhaled asthma drug may keep mild illness from worsening [04/17/2021]
• People with blood type A might be more susceptible to coronavirus, study finds [03/18/2020]
• People With Blood Type A May Be More Vulnerable to coronavirus, China Study Finds [03/17/2020]
• Shroud of Turin Bloodstains Likely Fake, Not of Jesus Christ: Forensic Experts [07/17/2018]
• California man offers truck, kidney to anyone who can help save dying wife [05/09/2018]
• What's your blood type? [10/21/2017]
• Shroud, New Study: There Is Blood of a Man Tortured and Killed [07/12/2017]
• Blood Groups And The History Of Peoples [04/18/2017]
• Scientists discover an enzyme that can change a person's blood type [05/03/2015]
• Pentagon's Giant Blood Serum Bank May Provide PTSD Clues [08/13/2013]
• A lot of old blood types as AB: Not Exactly -- Shroud.of Turin [04/21/2013]
• Newly discovered blood protein solves 60-year-old riddle [04/10/2013]
• Bacteria-killing proteins cover blood type blind spot [02/14/2010]
• In Japan, you are what your blood type is [02/04/2009]
• European Neanderthals had ginger hair and freckles [ and Type O blood ] [12/30/2008]
• AB Negative Blood Types In Northern Ireland. [03/31/2008]
• Transplant triggers blood-type change [01/24/2008]
• Ancient DNA Reveals Neandertals With Red Hair, Fair Complexions [10/28/2007]
• Medieval DNA, Modern Medicine (Lessons From The Black Death) [10/16/2007]
• Breakthrough makes all blood types universal [04/04/2007]
• Straw Poll Links Blood Type With Investment Savvy [09/17/2006]
• On The Presence Of Non-Chinese At Anyang [08/16/2006]
• Origins Of The Ainu [02/02/2006]
• British Have Changed Little Since Ice Age, Gene Study Says [07/26/2005]
• Blood Type History, Human Migrations (Blam Thread) [07/03/2005]
• Genetic Makeup in E. Asia (blood type Gm gene) [06/21/2005]
• BLOOD TYPE FOUND IN ICONS IS SAME AS IN SHROUD OF TURIN AND 'LANCIANO MIRACLE' [02/08/2005]
• Black Death Mutant Gene Resists AIDS, Say Scientists (Virus) [01/04/2005]
• The Relationship Between The Basque And Ainu [06/25/2004]

[SunkenCiv]

[SunkenCiv]

I think the ER has encountered blood groups before...

[SunkenCiv]

https://en.wikipedia.org/wiki/Blood_type

https://en.wikipedia.org/wiki/Er_blood_group_system

[momincombatboots]

O good.. I just need to know if it causes hemolytic transfusion reaction, delayed hon or hemolytic disease of the newborn. Blood banker bump.

[SunkenCiv]

:^)

[alexander_busek]

I would be interested in knowing if this new blood type were more-frequently encountered in specific ethnic groups. Unfortunately, the Wikipedia article is quite short, and says nothing about that.

Regards,

[ComputerGuy]

Interesting stuff.

[blam]

"I would be interested in knowing if this new blood type were more-frequently encountered in specific ethnic groups. Unfortunately, the Wikipedia article is quite short, and says nothing about that."

(ahem) The people who need to know that have already been told.

[Getready]

I wonder if piezo1 is seen in other families of blooded creatures. So now there are a total of 44 distinct blood groupings in humans. Keeps getting more complicated, not less.

[SunkenCiv]

Probably will be more, all rare. The difference between A and B, in the enabling sequences on chromosome 9, are something like 16 base pairs. Type O is the same sequence as type A, but with the first base pair missing, making all the three-pair genes gibberish.

https://en.wikipedia.org/wiki/Blood_type#Other_blood_group_systems

[SunkenCiv]

https://freerepublic.com/focus/chat/4109304/posts?page=11#11

[Buttons12]

They’re among us.

[Verginius Rufus]

Is the new blood group named for Er, the first-born son of Judah (Genesis 38.3)?

[SunkenCiv]

"Helix, make mine a double" keyword selections:

• Blood type may offer insights into risk of blood clot in people with cancer (All non-O blood types have venous thromboembolism risk at three months after any cancer diagnosis) [04/13/2022]
• Geneticists Just Got Closer to The Sources of Lung Cancer in People Who Never Smoked [09/09/2021]
• Neandertal and Denisovan blood groups deciphered [08/08/2021]
• Scientists Sequence Y Chromosome DNA of Denisovans and Neanderthals [09/27/2020]
• New study of Iceman reveals oldest known example of red blood cells [05/09/2015]
• Scientists discover an enzyme that can change a person's blood type [05/03/2015]
• Police can now tell identical twins apart -- just melt their DNA [04/27/2015]
• Scientists Have Found An Ancient Fossilized Mosquito Full Of Blood (46 Million Years OLD) [10/14/2013]
• Blood of the Irish: DNA Proves Ancestry of the People of Ireland [07/13/2013]
• Newly discovered blood protein solves 60-year-old riddle [04/10/2013]
• Otzi the Iceman: scientists find 5,000-year-old blood sample [05/03/2012]
• King Tut died of blood disorder: German researchers [ sickle cell disease ] [06/25/2010]
• Greenland Vikings 'had Celtic blood' [03/23/2010]
• Bacteria-killing proteins cover blood type blind spot [02/14/2010]
• European Neanderthals had ginger hair and freckles [ and Type O blood ] [12/30/2008]
• Clues to Black Plague's Fury in 650-Year-Old Skeletons [01/28/2008]
• Transplant triggers blood-type change [01/24/2008]
• Pacific Islanders' Ancestry Emerges in Genetic Study [01/18/2008]
• Blood Type History, Human Migrations (Blam Thread) [07/03/2005]
• New Insight Into Horse Evolution [07/03/2005]
• The origin of M1 mitochondrial DNA haplotype [06/23/2005]
• Genetic Makeup in E. Asia (blood type Gm gene) [06/21/2005]

[SunkenCiv]

No, but Erkel was.

[cuz1961]

Do those with this blood type have 6 fingers and toes or are unusually tall ?

Just curious.

[Pelham]

ping