Posted on 09/27/2022 9:50:08 PM PDT by ConservativeMind
Cycles of a diet that mimics fasting appear to reduce signs of Alzheimer's in mice genetically engineered to develop the illness.
The researchers found that mice that had undergone several cycles of the fasting-mimicking diet showed less Alzheimer's pathology. The researchers found lower levels of two major hallmarks of the disease: amyloid beta—the primary driver of plaque buildup in the brain—and hyperphosphorylated tau protein. They also found that brain inflammation lessened and better performance on cognitive tests compared to the mice that were fed a standard diet.
The fasting-mimicking diet (FMD) is high in unsaturated fats and low in overall calories, protein, and carbohydrates and is designed to mimic the effects of a water-only fast while still providing necessary nutrients.
Alongside healthy mice, the team investigated two mouse models of Alzheimer's.
In both models, mice who underwent FMD cycles showed promising reductions in amyloid beta—which form the sticky, disruptive plaques in the brain—and tau pathology compared to mice eating a standard diet. The FMD mice also showed lower levels of brain inflammation, including a reduction in the number of active microglia, the immune cells that seek and destroy pathogens and damaged cells in the brain. The study specifically pointed to the free radical "superoxide" as a central culprit in the damage occurring in these Alzheimer's mouse models, Longo explained.
The Alzheimer's mice given the FMD significantly outperformed the Alzheimer's mice given standard diets and in some instances performed similarly to the non-Alzheimer's-prone control mice, indicating that cognitive decline had been significantly slowed.
Longo and colleagues also included data from a small Phase 1 clinical trial of the fasting-mimicking diet in human patients diagnosed with mild cognitive impairment or mild Alzheimer's disease.
Initial data indicates that the FMD is safe and feasible for patients with mild impairment or early Alzheimer's disease.
(Excerpt) Read more at medicalxpress.com ...
Some hopeful news for a terrible disease!
Study shows that the amino acid taurine could be used in anti-aging therapy
https://freerepublic.com/focus/f-chat/4080060/posts
To best create the several needed forms, be sure to get 100% of the US RDA for manganese, zinc, and copper, which together create two needed forms of SOD.
Please elaborate..what supplements would be needed?
First, the fast-mimicking diet helps with reducing Alzheimer’s issues, nearly back to normal, as this study states, for only some markers. This is a diet you can look up, but it is a low calorie diet for several days, followed by a more normal diet, then cycling through it, again.
The use of taurine to create superoxide dismutase (SOD) is mentioned in that link. There are several forms of SOD our bodies need, and one requires manganese (just 100% of the US RDA a day) and the other requires copper and zinc (again, just 100% of the US RDA).
The taurine study used 500 mg of powder three times a day, but said doubling that likely would increase the SOD creation, which, in light of this Alzheimer’s study, would eliminate sone if the excess superoxide generation Alzheimer’s appears to create.
Ok thank you..
So, 1500mg of taurine?
Looking for anything to help my mom
Works on mice? Mice and rats are very similar so your saying there may be a cure for Biden coming?
Apologies, 1000 mg is double ;)
That taurine study used 500 mg three times a day, equalling 1,500 mg of taurine in a day. This increased superoxide dismutase (SOD) by over 20% in study participants over the 16 weeks it was given.
Superoxide dismutase (SOD) is the major reducer of the superoxide radical in our bodies, which the Alzheimer’s study says caused damage from Alzheimer’s.
There is more to read at that link and on the link to the original write up at Medical Xpress.
How do you tell if a mouse has Alzheimer’s?
It has always been about diet and exercise. All the studies in the world and all the pills in China will not change the fact that if you eat right and exercise every day you will have a good life.
>> a terrible disease
among the worst
>> How do you tell if a mouse has Alzheimer’s?
when it tells you that you’re fugly as sh#t
LOL!
Amen. Both of which few want to actually do (including myself) hence the drive to find a shortcut.
However, since menopause hit and all the attendant symptoms including weight gain, I decided F this. It took three or so months but dropped about 23 pounds with ... wait for it ... diet and exercise ... now at 133 lbs. and into my high school Levi 501s.
Was it a pain in the nads? Yes. But I wanted the size 6 more than I wanted the very transitory bliss of eating something I shouldn't.
Third, this is just a mouse study.
They did a small study with human patients to see if Alzheimer’s patients could handle a fast-mimicking diet, and they could.
Sure, it’s easy to forget that you haven’t eaten...
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