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To: CheshireTheCat

🚨BREAKING: Biden Crime Family expert and investigator Peter Schweitzer declares Hunter Biden is going to be INDICTED: “Hunter’s legal team cooperation indicate the president’s son is about to be indicted.”

This is the end. pic.twitter.com/wwwaKB50Bl— Benny (@bennyjohnson) March 20, 2022

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Sir Francis Bacon March 21, 2022 3:13 pm

Without these lipid shells, there would be no mRNA vaccines for COVID-19 Fragile mRNA molecules used in COVID-19 vaccines can’t get into cells on their own. They owe their success to lipid nanoparticles that took decades to refine!!!

by Ryan Cross

March 6, 2021 | A version of this story appeared in Volume 99, Issue 8

Luckily, scientists found a solution. To protect the fragile molecule as it sneaks into cells, they turned to a delivery technology with origins older than the idea of mRNA therapy itself: tiny balls of fat called lipid nanoparticles, or LNPs.

LNPs used in the COVID-19 vaccines contain just four ingredients: ionizable lipids whose positive charges bind to the negatively charged backbone of mRNA, pegylated lipids that help stabilize the particle, and phospholipids and cholesterol molecules that contribute to the particle’s structure. Thousands of these four components encapsulate mRNA, shield it from destructive enzymes, and shuttle it into cells, where the mRNA is unloaded and used to make proteins. Although the concept seems simple, perfecting it was far from straightforward.

Over more than 3 decades, promising lipids studied in the lab often failed to live up to their potential when tested in animals or humans. Positively charged lipids are inherently toxic, and companies struggled for years before landing on formulations that were safe and effective. When injected intravenously, the particles invariably accumulated in the liver, and delivery to other organs is still an obstacle. Reliably manufacturing consistent LNPs was another challenge, and producing the raw materials needed to make the particles is a limiting factor in the production of COVID-19 vaccines today.

LNP development has been a headache, but without this packaging, mRNA vaccines would be nothing. “It is the unsung hero of the whole thing,” says Giuseppe Ciaramella, who was head of infectious diseases at Moderna from 2014 to 2018.<———————

https://cen.acs.org/pharmaceuticals/drug-delivery/Without-lipid-shells-mRNA-vaccines/99/i8

(How does this lipid shell interact with lipids in the body? What about people who have high or low lipid natural lipid levels?)

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Sir Francis Bacon March 21, 2022 2:03 pm

The last few patents on COVID-19 were reportedly completed in Wuhan, with the last of these in 2019. So it should be possible to see which version showed up in the patents, against which version was released or escaped? I think, this would be very revealing.

Let’s just get the bottom of this mystery. Look at all the patents filed in Wuhan and work backward.

DR Martin –

https://drive.google.com/file/d/19o1BeQa6z9XD58GkYE1e-qiiNbnr5wTz/view

if you actually take what they report to be novel, you find 73 patents issued between 2008 and 2019 which have the elements that were allegedly novel in the SARS COV-2, specifically as it relates to the polybasic cleavage site, the ACE-2 receptor binding domain, and the spike protein. So the clinically novel components of the clinically unique, clinically contagious, you know where I’m going with this, okay…

There was no outbreak of SARS, because we had engineered all of the elements of that, and by 2016, the paper that was funded during the gain-of-function moratorium, that said that the SARS coronavirus was poised for human emergence, written by none other than Ralph Barrack, was not only poised for human emergence, but it was patented for commercial exploitation, 73 times.

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Sir Francis Bacon March 21, 2022 2:02 pm

It’s about 1 hour to read through his research

Lab-Made? SARS-CoV-2 Genealogy Through the Lens of Gain-of-Function Research

Apr 22, 2020

By Yuri Deigin

“Oh, and I am not sure how in 2015 Baric was granted a patent for the creation of “chimeric coronavirus spike proteins”, given all that he and Shi Zhengli previously disclosed in their papers long before 2015”.

https://yurideigin.medium.com/lab-made-cov2-genealogy-through-the-lens-of-gain-of-function-research-f96dd7413748

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Sir Francis Bacon March 21, 2022 1:54 pm

Moderna wanted the LIPIDS patents for mRNA. So the Battle started

The mRNA IP and Competitive Landscape Through One Year of the COVID-19 Pandemic – Part I

Moderna has indicated it has over 270 issued or allowed U.S. and foreign patents protecting mRNA-based technology, with over 600 worldwide pending patent applications. The company has identified at least seven granted U.S. patents that it alleges protect its COVID-19 mRNA-1273 vaccine.

Moderna appears to have sub-licensed foundational mRNA patents from Cellscript, LLC based on advancements made by Drs. Katalin KarikĂł and Drew Weissman at the University of Pennsylvania (UPenn) in the 2000s. The KarikĂł-Weissman team addressed adverse immune responses to injected synthetic mRNA by replacing the nucleosides uridine and cytidine in the mRNA with pseudouridine and 5-methylcytidineone. Cellscript itself has a sub-license from its affiliate mRNA RiboTherapeutics, Inc., which holds an exclusive license from UPenn.

An exemplary patent resulting from this work is U.S. Patent No. 8,278,036, which

Continue read

https://www.ipwatchdog.com/2021/04/11/mrna-ip-competitive-landscape-one-year-covid-19-pandemic-part/id=132130/ ___________________

1,017 posted on 03/21/2022 6:51:33 PM PDT by CheshireTheCat ("Forgetting pain is convenient.Remembering it agonizing.But recovering truth is worth the suffering")
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To: goldbux

* * * Liquid nanoparticle [LNP] shells protect mRNA molecules for delivery. * * *


1,066 posted on 03/21/2022 10:38:14 PM PDT by goldbux (“The whole world is a very narrow bridge. The main thing is to have no fear at all.” -- Nachman)
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To: CheshireTheCat

You win the thread. Bookmarked.


1,119 posted on 03/22/2022 5:46:12 AM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: nclaurel

Bkmk


1,120 posted on 03/22/2022 5:49:14 AM PDT by nclaurel (Twice denied my “basic human rights” by being Double Banned by Twitter Communists)
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