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I’m well aware of Uttar Pradesh - home of the Kappa variant, July 2021, pre-vaccine.

Ivermectin might have helped those that had worms, but the wave of Delta in Uttar in 2021 killed over 22,000 in a short period of time - some dying from lack of oxygen and oxygen rationing inside and outside of hospitals on the street. How could that be if ivermectin was so great as a early treatment? What saved Uttar was mass vaccinations. They are now over 76% vaccinated and aiming for 90%. Only 9% surveyed said they’d refuse the vaccine.

https://scroll.in/article/1013100/how-vaccine-fatigue-in-uttar-pradesh-could-be-addressed-with-behavioural-science
https://www.firstpost.com/india/no-death-due-to-lack-of-oxygen-during-covid-19-second-wave-claims-uttar-pradesh-government-10216211.html

But are we to believe the govt of India is stupid? That they would spend all that money on getting people vaccinated if an off-the-shelf actually worked? Or that everyone in Uttar Pradesh is stupid, too? That they would take a vaccine after the wave is over, instead of a home remedy? Are we to believe the RECOVER study and the McMasters Study that showed no benefit, and no benefit in any South American country, or the Japanese, are all wrong?

And the question still remains, why would something with low efficacy against a weaker virus in 2020 suddenly have higher efficacy against a stronger virus in 2021? Ivermectin resistance is well documented; worms can build resistance but a virus can’t? That’s a lot of wishing to try to make something true.

How could that be if ivermectin was so great as a early treatment?

By the end of 2020: Uttar Pradesh had crushed the Covid outbreak that had mauled the rest of india. They did this by by deploying ivermectin to the population.

In 2021 the Delta wave hit India. By its peak in May 2021: hundreds of thousands of seasonal migrants had fled Mumbai (and other big cities) back to their home towns and villages.

Those who settled back into their villages in Uttar Pradesh had (of course) not received ivermectin. This meant that Uttar Pradesh saw the same spike in cases that every other Indian state.

Remember that Ivermectin is (amongst other things) a protease inhibitor. One of its actions is to suppress viral replication.

But if you wait until the virus has fully replicated, and people are being brought to the hospital with lung damage caused by the virus, then antivirals are of no use.

At that stage you trying to keep patients alive with oxygen, heparin and thiamine while mitigating the tissue damage with steroids & vit-C.

But are we to believe the govt of India is stupid? That they would spend all that money on getting people vaccinated if an off-the-shelf actually worked?

You clearly have an extraordinarily rosy view of government.

Public officials in Uttar Pradesh may be crowing about their vaccination rate. After all: this is what public officials do. They boast about wasting public funds and then ask for more. See also: every country in the world.

The UKSHA (UK Health Security Agency) figures famously showed no useful improvement in Covid deaths from the use of vaccines.

If we compare deaths by cohort to vaccination rate by cohort then there is maybe 10% extra survivability in the very oldest cohort. This is nowhere near as effective as simple prophylaxis with Zinc + an ionophore, Vitamin D, Vitamin C. Or the use of nasal disinfectants.

The vaccines in the UK have certainly had nothing like the efficacy you would expect from something called a 'vaccine'.

The vaccines have been a huge, expensive failure in the UK - and that's before we consider the mind-numbing loss and destruction wrought so-far by the 'clot-shot'. So why would the vaccines work any better in India?

What has actually happened is that most people have had Covid - sometimes without realising it - and now have natural immunity. They would be fine - if their immune systems weren't damaged by vaccine trauma.

Ivermectin resistance is well documented; worms can build resistance but a virus can’t?

Compared with a helminth, a virus is not a complex organism. A virus would have to mutate into a different strain in order to develop resistance to inhibition. Which can certainly happen, and one would expect covid variants that develop a resistance to some antivirals.

But Ivermectin has multiple pathways: it not only inhibits viral replication but also prevents viral attachment (with the infamous spike protein). Also: it is an anti-inflammatory. It is not an early candidate for viral resistance, unlike single-action anti-virals.