Study reveals existing drugs that kill SARS-CoV2 in cells (lactoferrin supplement best for safety and common availability)

Science Daily / Proceedings of the National Academy of Sciences ^ | Kelly Malcom / Carmen Mirabelli, Jesse W. Wotring, Charles J. Zhang, Sean M. McCarty, et al

[ConservativeMind]

Since the beginning of the pandemic, researchers worldwide have been looking for ways to treat COVID-19. And while the COVID-19 vaccines represent the best measure to prevent the disease, therapies for those who do get infected remain in short supply. A new groundbreaking study from U-M reveals several drug contenders already in use for other purposes -- including one dietary supplement -- that have been shown to block or reduce SARS-CoV2 infection in cells.

The study uses artificial intelligence-powered image analysis of human cell lines during infection with the novel coronavirus. The cells were treated with more than 1,400 individual FDA-approved drugs and compounds, either before or after viral infection, and screened, resulting in 17 potential hits. Ten of those hits were newly recognized, with seven identified in previous drug repurposing studies, including remdesivir, which is one of the few FDA-approved therapies for COVID-17 in hospitalized patients.

The team validated the 17 candidate compounds in several types of cells, including stem-cell derived human lung cells in an effort to mimic SARS-CoV2 infection of the respiratory tract. Nine showed anti-viral activity at reasonable doses, including lactoferrin, a protein found in human breastmilk that is also available over the counter as a dietary supplement derived from cow's milk.

"We found lactoferrin had remarkable efficacy for preventing infection, working better than anything else we observed," Sexton said. He adds that early data suggest this efficacy extends even to newer variants of SARS-CoV2, including the highly transmissible Delta variant.

Sexton noted that over the course of the pandemic, other drug repurposing studies have identified different compounds with potential efficacy against SARS-CoV2. "The results seem to be dependent on what cell system is used," he said.

[Cboldt]

-- *Would it be better to hire a Wet Nurse? --

This calls for a dry one ....

[Uncle Miltie]

Bkmk

[Faith65]

Thanks.
BFL

[itsahoot]

They can’t keep lactoferrin from you!

----You watch . . . they'll try. . . .

No but they can make it very expensive. Durvet Ivermectin was from $5 to $11 last week now Amazon has it listed for $47.00 a tube. Couldn't even get it to show up yesterday on Amazon, or day before.

[steve86]

I like the new Carmel flavor. Have to stop myself from taking too much.

[Eagles6]

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