That is insane, we really are living in an Idiocracy!
Posted on 07/18/2021 8:30:35 PM PDT by SeekAndFind
As Mumbai city’s management and medical experts prepare for an anticipated third wave of Covid-19, an experimental drug has offered a glimmer of hope against the virus.
Known as monoclonal antibody cocktail, the drug’s response has been analysed in 199 patients who were admitted to Mumbai’s Seven Hills Hospital, and the findings are promising, say doctors. Their analysis underlined two important findings – persistent fever in patients resolved within 48 hours and the days of hospitalisation were reduced. This suggests that the drug could play a role in reducing the number of severe Covid-19 cases and thereby the fatality. More studies with larger sample sizes can provide a better understanding of the drug’s usefulness in the fight against Covid-19.
Here’s everything that we know about monoclonal antibodies and the drug cocktail.
When our bodies are attacked by an infection caused by viruses or bacteria, they produce natural antibodies or proteins to fight back. These antibodies are crucial in our immune system’s defence mechanism. Monoclonal antibodies are similar to natural antibodies except that they are laboratory-made. They are designed to target a specific disease and are often referred to as ‘designer antibodies’.
Monoclonal antibodies have been widely used in cancer and autoimmune diseases. A 2020 review published in the Journal of Biomedical Science stated that antibody engineering has evolved dramatically since the first monoclonal antibody was approved by the US Food and Drug Administration in 1986 and over the past five years, antibodies have become the best-selling drugs in the pharmaceutical market worldwide.
A monoclonal antibody cocktail drug is a combination of two or more monoclonal antibodies that are administered to patients. Last November, the US FDA issued an emergency use authorisation to REGEN-COV, which contains two monoclonal antibodies – casirivimab and imdevimab – to be administered together for treating mild to moderate Covid-19 patients. The cocktail is indicated for adults and paediatric patients (12 years of age or older weighing at least 40 kg) who were at the risk of progressing to severe Covid-19. India granted an emergency use authorisation to the drug in May and it is the same used by doctors at Seven Hills Hospital. The drug is available in India through a tie-up between Roche India and Cipla.
There are other monoclonal antibody drugs in the fray for Covid-19. In June, India’s drug regulator gave an emergency use approval to American pharmaceutical company Eli Lilly’s antibody-drug combination – bamlanivimab and etesevimab. The same month, Indian company Zydus Cadila was granted permission to conduct clinical trials for its antibody-drug therapy.
The monoclonal antibodies mimic the actions performed by natural antibodies during an attack by a pathogen. For instance, casirivimab and imdevimab present in REGEN-COV are specifically made to target the spike protein of SARS-CoV-2, designed to block the virus’ attachment and entry into human cells.
“Thanks to its specific engineering of two neutralising antibodies which bind to different parts of the virus spike, the casirivimab and imdevimab cocktail remains efficacious against the widest spreading variants and reduces the risk of losing its neutralisation potency against new emerging variants,” said a release from Cipla.
Doctors who have used the cocktail drug said that timing is the key to get good results.
“One must also select the patients carefully,” said infectious disease specialist Dr Tanu Singhal, who practices at Mumbai’s Kokilaben Dhirubhai Ambani Hospital
My allergy/asthma PA said she’d start me immediately on monoclonal antibodies should I test positive for Covid (I’m 72). She said she’s had universally positive results but taking it ASAP was critical.
Excellent advice. Please follow it
In my judgment, it is medically irresponsible to advocate for anything of a lesser standard.
People should know their options. It’s irresponsible to assume that this treatment will always be available in the future regardless of where they are.
That is insane, we really are living in an Idiocracy!
Colloidal silver is. Has been and always will be THE most effective anti bacterial and anti viral known to man
Bugs CANNOT create resistance to it
I know you mean well, but silver is NOT the right way to go if you get the coof....
Demand monoclonal antibody treatment immediately after testing positive.
seriously...
There is more than enough medications available. There are more than enough infusion centers. With appropriate advocacy for the patient — there is no reason that anyone who meets criteria should not have this life saving treatment. There are no other equal alternatives to treatment at this time.
Colloidal silver is not a treatment, has been widely studied and does not meet criteria for any treatment and has far more risk than benefit. There is no reason that anyone should forgo life saving treatment for something that exists only on the fringe. Most certainly if there was a silver bullet for all infection, it would be in wide use, there is a reason colloidal silver is not in wide use.
There is more than enough medications available. There are more than enough infusion centers. With appropriate advocacy for the patient — there is no reason that anyone who meets criteria should not have this life saving treatment. There are no other equal alternatives to treatment at this time.
All sounds great. Meanwhile, a patient who can’t access it because everything you say should happen is not happening this month, should know his options.
I know you are an Ivermectin proponent. As I stated, with immediate attention at the onset of symptoms, at this time, there is no one who will not get the treatment. This is the best treatment option, this is the closest to a cure, and is absolutely the best medicine available. Please instead of trying to detract from this life saving therapy, stop promoting weaker and less effective treatments.
Yeah, there’s still a place for ivermectin (and other treatments.) I’m over 55 but with no risk factors. I wouldn’t qualify for monoclonal antibody infusion. I’ve been vaccinated, but if I’m unlucky enough to be a breakthrough COVID case, I won’t be waiting around doing nothing and just hoping it won’t go from mild to moderate to severe. I’ll be doing Kory’s approach or something similar.
“As I stated, with immediate attention at the onset of symptoms, at this time, there is no one who will not get the treatment.”
Even someone under 65 with no risk factors can get monoclonal antibody infusion now?
That would be a big step in the right direction if true.
The first I heard of this is when I had a video visit with a doctor on call. She sent me for a Covid test and said since my chart shows I have a risk factor she will prescribe that if I end up testing positive. A very good doctor. This was when most were just telling patients theres not much can be done, stay home and go to ER if you can’t breathe :(
Thanks for sharing. I am appalled at the amount of primary docs who have no idea of this.
It is criminal. This is the safe and effective cure many hope for. I will use the FLCCC statement. Vaccines and treatment are equally as important in the control of the disease. More and more there is clear data demonstrating this is the best treatment. I very much so advocate vaccination. However I never believe it should be mandatory
Here in front of us is a safe treatment that is highly effective. If someone doesn’t want vaccination here is an excellent treatment wirh highly reproducible results unlike other medications.
Just get the vaccinations and quit worrying about the voodoo treatments showing up on the internet.
Mom MD yesterday wrote “Monoclonal antibody therapy and Decadron (dexamethasone) was the only treatment I cared about and made sure happened in a timely fashion.” (interestingly, drugs.com says “The Decadron brand name has been discontinued in the U.S.).
Are you prescribing/recommending dexamethasone in conjunction with MABs?
Here is their page for Infusion patients: Infusion Patients: Here you can find resources created for patients treated with COVID-19 antibody therapeutics.
And here is the NICA COVID-19 Antibody Therapy Locator page.
And they are really fun to make!
“Glimmer of hope.”
GEEESH.
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