Posted on 04/10/2020 6:05:33 PM PDT by SeekAndFind
The new study, of which the abstract was released today, was performed at IHU Méditerranée Infection, Marseille, France. A cohort of 1061 COVID-19 patients, treated for at least 3 days with the Hydroxychloroquine-Azithromycin (HCQ-AZ) combination and a follow-up of at least 9 days was investigated.
Key findings are:
A poor outcome was observed for 46 patients (4.3%); 10 were transferred to intensive care units, 5 patients died (0.47%) (74-95 years old) and 31 required 10 days of hospitalization or more.
The authors conclude that:
“The HCQ-AZ combination, when started immediately after diagnosis, is a safe and efficient treatment for COVID-19, with a mortality rate of 0.5%, in elderly patients. It avoids worsening and clears virus persistence and contagiosity in most cases.”
See the complete abstract below.
The original abstract can be accessed here.
Also, the researchers made this table available.
It’s not clear when the complete study will be made available.
ABSTRACT
Background
In a recent survey, most physicians worldwide considered that hydroxychloroquine (HCQ) and azithromycin (AZ) are the two most effective drugs among available molecules against COVID-19. Nevertheless, to date, one preliminary clinical trial only has demonstrated its efficacy on the viral load. Additionally, a clinical study including 80 patients was published, and in vitro efficiency of this association was demonstrated.
The study was performed at IHU Méditerranée Infection, Marseille, France. A cohort of 1061 COVID-19 patients, treated for at least 3 days with the HCQ-AZ combination and a follow-up of at least 9 days was investigated. Endpoints were death, worsening and viral shedding persistence.
Findings
From March 3rd to April 9th, 2020, 59,655 specimens from 38,617 patients were tested for COVID-19 by PCR. Of the 3,165 positive patients placed in the care of our institute, 1061 previously unpublished patients met our inclusion criteria. Their mean age was 43.6 years old and 492 were male (46.4%). No cardiac toxicity was observed. A good clinical outcome and virological cure was obtained in 973 patients within 10 days (91.7%). Prolonged viral carriage at completion of treatment was observed in 47 patients (4.4%) and was associated to a higher viral load at diagnosis (p < 10-2) but viral culture was negative at day 10 and all but one were PCR-cleared at day 15. A poor outcome was observed for 46 patients (4.3%); 10 were transferred to intensive care units, 5 patients died (0.47%) (74-95 years old) and 31 required 10 days of hospitalization or more. Among this group, 25 patients are now cured and 16 are still hospitalized (98% of patients cured so far). Poor clinical outcome was significantly associated to older age (OR 1.11), initial higher severity (OR 10.05) and low hydroxychloroquine serum concentration. In addition, both poor clinical and virological outcomes were associated to the use of selective beta-blocking agents and angiotensin II receptor blockers (P<0.05). Mortality was significantly lower in patients who had received > 3 days of HCQ-AZ than in patients treated with other regimens both at IHU and in all Marseille public hospitals (p< 10-2).
The HCQ-AZ combination, when started immediately after diagnosis, is a safe and efficient treatment for COVID-19, with a mortality rate of 0.5%, in elderly patients. It avoids worsening and clears virus persistence and contagiosity in most cases.
There’s an interesting article on how hydroxychloroquine works in the case of other diseases here:
https://www.nature.com/articles/s41584-020-0372-x
Review Article
Published: 07 February 2020
Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology
Eva Schrezenmeier & Thomas Dörner
Nature Reviews Rheumatology volume 16, pages155–166(2020)Cite this article
Sounds equal to the fatality rate without it. Am I missing something?
RE: Sounds equal to the fatality rate without it. Am I missing something?
I think you’re missing the CONDITION of the patient before going on the HCQ+Azithromycn regiment.
Again, all studies, including Dr. Raoult’s show that:
1. It has to be applied as soon as: a) The patient is CoVid-19 positive; and b) shows fever, coughing and/or breathing problems.
2. Do not wait till the lungs are so compromised and damaged by pneumonia and the patient needs a respirator.
If you do the above, all experience shows that the patient gets better with 6 days.
This significantly eases the burden of hospitals and healthcare workers and also reduces the death rate.
If you administer it when the patient is already on a respirator, the effectiveness goes down. The lungs could already be damaged. There’s still a chance the patient recovers as other cases show, but effectivity is not guaranteed.
Also, Zinc is a major component of the treatment.
What many doctors observe is that the virus uses the cell as a platform to replicate. Because this invader is new, the immune system overreacts (especially true for mature individuals like the elderly) and creates what is known as a Cytokine storm, sort of like a soldier shooting at everything in sight, not differentiating between the good and bad guys, thus, killing the good as well. This causes ARDS (Acute Respiratory Distress Syndrome), where fluid collects in the lungs and air sacs depriving oxygen.
Hydroxychloroquine acts as an ionosphere where Zinc can work to prevent the virus from replicating. Hydroxychloroquine also acts to modulate autoimmune response ( much like it does lupus ), so that the immune system’s cytokine storm calms down giving the body the chance to fight off the invader without killing its own healthy lung cells.
Azithromycin is used to fight possible bacterial infection.
IN SUM:
These 3: HCQ+AZITHROMYCIN+ZINC, given at the right doses EARLY before the disease has the chance to progress to a more severe state is what accounts for most of the success.
Dr. Didier’s latest study simply reinforces these.
I have a rather frail cousin about my age who took HCQ for eighteen years, 400mg QD, every day. Her only symptom was a reduction in her RA discomfort.
If I interpret the data at https://www.mediterranee-infection.com/covid-19/ correctly, 0.5% is about one-third the mortality rate at two Marseille hospitals near Dr. Raoult's institute, for COVID-19 patients who did not receive HCQ-AZ.
Also, HCQ-AZ is said to reduce patient viral loads, which shortens the duration of illness and and reduces contagion. We'll have to wait for the full study to be published to get the details.
So, Trump is right again!
That’s some righteous dude right there!
“Sounds equal to the fatality rate without it. Am I missing something?”
Yes, this...
“A recent study of COVID-19 cases in the United States estimated a mortality rate of 10% to 27% for those ages 85 and over, 3% to 11% for those ages 65 to 84, 1% to 3% for those ages 55 to 64 and less than 1% for those ages 20 to 54.”
From...https://www.livescience.com/is-coronavirus-deadly.html
“In addition, both poor clinical and virological outcomes were associated to the use of selective beta-blocking agents and angiotensin II receptor blockers (P<0.05).”
Hmmm... I’m 71 and taking both of those meds.
“These 3: HCQ+AZITHROMYCIN+ZINC, given at the right doses EARLY before the disease has the chance to progress to a more severe state is what accounts for most of the success.
Dr. Didier’s latest study simply reinforces these.”
Zinc is not mentioned in this report. A lot of things I read seem to indicate that it’s a key ingredient, yet he’s not using it. I wonder why.
If the distancing goes on much longer, I will be approaching the doctor’s hair length. I have angel wings behind my ears. When I was ten I had a ‘ducktail’ hairdo. At 74 I am almost there again!
Acts as an ‘ionosphere” LOL, that typo is even more funny than my fox paw which Lazamataz explained ... ‘ionophone’. Maybe Laz can fix yours, also.
The French drink lots of red wine which is high in zinc.
Good link, thanks.
Thank God. I think HCQ has had a major impact on this disease.
What is really remarkable in this study is that even more patients under hospital care did mot succumb due to medicl malfeasance.
I don’t think Raoult uses zinc. wish he did. And the word is ionophore — you may be a victim of auto-complete.
I don’t think Raoult uses zinc. wish he did. And the word is ionophore — you may be a victim of auto-complete.
I don’t think you understood my post. I was very impressed that deaths after using Chloroquine were so very very low and those who were cured was over 91%. Chloroquine is clearly very effective.
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