Not gonna work, in general, and highly unsafe.
WinME was the last of the MS-DOS family of Windows releases. The programs that are written for the NT family of Windows generally wont run on the MS-DOS family releases.
MS-DOS family (major releases): 1.0, 2.0, 3.1, 3.11, 95, 98, 98SE, ME.
NT family (major releases): NT3.1, NT3.5, NT4.0, 2000, XP, Vista, 7, 8, 8.1, 10.
The reason it probably wouldnt work for you is that the two families are generally incompatible, and programs that are written for the NT family almost never work on the MS-DOS family.
The reason its highly unsafe is that the MS-DOS family releases were never designed for security. They are wildly, insanely, insecure. They are terribly unprotected against virtually everything.
Finally, WinME was the last member of the MS-DOS family, and was designed to fail. It was intended to drive users away from the MS-DOS family and into the NT family. And it was so bad, that strategy worked.
The only thing anyone should use an MS-DOS family release for, these days, is an ancient but beloved program that wont run on the NT family releases, and then ONLY if the computer is NOT connected to the internet.
I've installed Linux Mint 19.3 on my other computer. What a long strange trip it is as my ability to learn has apparently shrunk with age (yeah, yeah...that's what HE said). But we're getting there with all the support it has. We now return to the normal channel...