[ConservativeMind]

High cortisol levels can be greatly attenuated with Vitamin C.

The vast majority of critical-level patients have very high cortisol and very low Vitamin C levels.

Perhaps supplementing those patients with Vitamin C could help them.

[NativeSon]

I like to take enough vitamin C supplements to make my urine sample appear radioactively vibrating.

[LadyDoc]

In the past, we routinely added vitamins to the iv fluid of the who were on ivs more tan a day or 2...

They stopped doing that but started to give iv hyperalimentation to the critically ill.

And the sick and injured have a high cortisol level because they need it...we often give it for sepsis because a weak body doesn't produce enough.

[RandallFlagg]

So, I shouldn’t eat my niece’s guinea pigs.
Got it.

[chrisser]

Im too lazy this morning to Google...is cortisol bad?

[MarMema]

Thank you for posting this. I had no idea.

[bert]

So, when you get sepsis as a result of a catheter while in a hospital bed, you should eat orangesto prevent death

[Right Wing Assault]

Thanks for the concise summary of that article.

[P.O.E.]

Which is why we evolved to make vodka to help us drink orange juice. Oh, and with cranberry juice on holidays.

[Openurmind]

From what I understand a proper balance of vitamin C with supplemental Calcium is also important?

[logi_cal869]

Well, yes...for critically-ill patients.

Otherwise we’re still talking about painting over dry-rot for everyone else, as cortisol is also produced as a response to general inflammation.

“Screwdriver” aficionados take note: You now have another arrow in your quiver to validate stress-response alcohol consumption. /s

[Pete from Shawnee Mission]

Thank you!

Ascorbic acid is part of a Sepsis protocol developed by a hospital in NJ. Share it.

https://pulmccm.org/critical-care-review/hydrocortisone-ascorbic-acid-and-thiamine-hat-therapy-in-sepsis-a-question-answer-with-dr-paul-marik/

Snip...”So I thought I had an obligation to try this again on our next patient with septic shock. This time we added intravenous thiamine to the mix … and the response was exactly the same as the first case. As all three agents are widely available and approved drugs which are devoid of side effects and extremely cheap - I felt I had an ethical obligation to continue to treat our patients with severe sepsis and septic shock with this cocktail. And indeed, the response was reproducible time over time over time. This led to us reporting our initial experience with this cocktail in a retrospective, before-after propensity adjusted study reported in Chest in June of 2017. We have to date treated over 850 patients with the same reproducible findings. In addition, hundreds of patients have been treated world-wide and this combination has become the standard of care in a number of hospital in the US and abroad.”

https://www.ncbi.nlm.nih.gov/pubmed/30441816

“Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid and Thiamine (HAT therapy) may reduce organ failure and mortality in patients with sepsis and septic shock. HAT therapy is based on the concept that a combination of readily available, safe and cheap agents, which target multiple components of the host’s response to an infectious agent, will synergistically restore the dysregulated immune response and thereby prevent organ failure and death. This paper reviews the rationale for HAT therapy with a focus on vitamin C.”