[ConservativeDude]

It would be tragic, but hardly surprising, if we found out clinically that even skin cancer was boosted by low vitamin D levels....

[DaxtonBrown]

[It would be tragic, but hardly surprising, if we found out clinically that even skin cancer was boosted by low vitamin D levels....]

My brother just survived melanoma. We think vitamin D deficiency was part of it.

[aruanan]

It would be tragic, but hardly surprising, if we found out clinically that even skin cancer was boosted by low vitamin D levels....

Or that changes in the body's metabolism and cell-signaling mechanisms induced by cancer result in low vitamin D levels--one such thing could be that vitamin D in the body is synthesized from cholesterol and a rapid proliferation of cancer cells requires cholesterol, thus depleting a substrate for vitamin D synthesis; another could be that since vitamin D is required for various nuclear hormone receptors having to do with cell growth and differentiation, the reduction of vitamin D could come from an increased use of it by rapidly proliferating cancer cells or from an attempt by the body to fight the rapid proliferation by reducing the amounts of vitamin D available for tumor proliferation.

On the other hand, it has been found to interfere with receptor tyrosine kinases, to inhibit cell proliferation, angiogenesis (absolutely required for tumor progression), as well as to facilitate cell differentiation (the loss of which sometimes results in cancer) and apoptosis (a way the cell kills itself when something goes awry).

[Williams]

Melanoma skin cancer IS higher among the sunlight/ vitamin D deficient.

[Williams]

Melanoma skin cancer IS higher among the sunlight/ vitamin D deficient.

[Williams]

Melanoma skin cancer IS higher among the sunlight/ vitamin D deficient.