Scientific evidence supports effectiveness of Chinese drug for cataracts

American Chemical Society ^ | January 12, 2011 | Unknown

[decimon]

Scientists are reporting a scientific basis for the long-standing belief that a widely used non-prescription drug in China and certain other countries can prevent and treat cataracts, a clouding of the lens of the eye that is a leading cause of vision loss worldwide. Their study appears in Inorganic Chemistry, an ACS journal.

In the study, Tzu-Hua Wu, Fu-Yung Huang, Shih-Hsiung Wu and colleagues note that eye drops containing pirenoxine, or PRX, have been reputed as a cataract remedy for almost 60 years. Currently, the only treatment for cataracts in Western medicine is surgical replacement of the lens, the clear disc-like structure inside the eye that focuses light onto the nerve tissue in the back of the eye. Despite the wide use of pirenoxine, there have been few scientific studies on its actual effects, the scientists note.

To fill that gap, the scientists tested pirenoxine on cloudy solutions that mimic the chemical composition of the eye lens of cataract patients. The solutions contained crystallin — a common lens protein — combined with either calcium or selenite, two minerals whose increased levels appear to play key roles in the development of cataracts. Presence of PRX reduced the cloudiness of the lens solution containing calcium by 38 percent and reduced the cloudiness of the selenite solution by 11 percent. "These results may provide a rationale for using PRX as an anti-cataract agent and warrant further biological studies," the article notes.

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The authors acknowledge funding from the National Science Council, Shin Kong Wu Ho-Su Memorial Hospital, and Academia Sinica (Taiwan).

ARTICLE FOR IMMEDIATE RELEASE "Ditopic Complexation of Selenite Anions or Calcium Cations by Pirenoxine: An Implication for Anti-Cataractogenesis"

DOWNLOAD FULL TEXT ARTICLE http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/ic102151p

CONTACT: Tzu-Hua Wu, Ph.D. School of Pharmacy College of Pharmacy Taipei Medical University Taipei, Taiwan Phone: 886-2-2736-1661 ext 6172 Fax: 886-2-27358920 Email: thwu@tmu.edu.tw

[rwbil]

I have tried Brite Eyes. Did not really see any difference. I would like to try this Chinese Pirenoxine eye drops, but can not find anywhere they are sold. Does anybody have a link.

[Windflier]

N-acetyl carnosine

Judith, I followed your link to the Bright Eyes cataract treatment product from a very dated post of yours. It sounds very intriguing.

Can you tell me what your long term experience was with the product? I'm very much in need of a solution.

Thank you.